ArticleEuropean heart journal2024
Pre-existing maternal cardiovascular disease and the risk of offspring cardiovascular disease from infancy to early adulthood.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Maternal Body Mass Index, Gestational Weight Gain, and Cardiovascular Disease in Offspring.JAMA network open · 2026Article
- Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study.PLoS medicine · 2026Article
- Prediction of Cyanotic Congenital Heart Disease Risk in U.S. Births.Journal of cardiovascular development and disease · 2026Article
- Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children.BMC medicine · 2026Article
- Black Parent's Perceptions of Discussing Cardiovascular Disease Risk with Primary Care Clinicians: a Qualitative Study.Journal of racial and ethnic health disparities · 2026Article
- Maternal nutritional imbalance during pregnancy and the development of fetal-origin cardiovascular diseases.Frontiers in nutrition · 2026Review
- Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States.Journal of the American Heart Association · 2025Article
- Beyond Genes: Mechanistic and Epidemiological Insights into Paternal Environmental Influence on Offspring Health.Current environmental health reports · 2025Review
- Lactation safety of cardiovascular medications.American heart journal plus : cardiology research and practice · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
aimsA variety of maternal heart conditions are associated with abnormal placentation and reduced foetal growth. However, their impact on offspring's long-term cardiovascular health is poorly studied. This study aims to investigate the association between intrauterine exposure to pre-existing maternal cardiovascular disease (CVD) and offspring CVD occurring from infancy to early adulthood, using paternal CVD as a negative control.
methodsThis nationwide cohort study used register data of live singletons without major malformations or congenital heart disease born between 1992 and 2019 in Sweden. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for essential maternal characteristics. Paternal CVD served as a negative control for assessment of unmeasured genetic and environmental confounding.
resultsOf the 2 597 786 offspring analysed (49.1% female), 26 471 (1.0%) were born to mothers with pre-existing CVD. During a median follow-up of 14 years (range 1-29 years), 17 382 offspring were diagnosed with CVD. Offspring of mothers with CVD had 2.09 times higher adjusted HR of CVD (95% CI 1.83, 2.39) compared with offspring of mothers without CVD. Compared with maternal CVD, paternal CVD showed an association of smaller magnitude (HR 1.49, 95% CI 1.32, 1.68). Increased hazards of offspring CVD were also found when stratifying maternal CVD into maternal arrhythmia (HR 2.94, 95% CI 2.41, 3.58), vascular (HR 1.59, 95% CI 1.21, 2.10), and structural heart diseases (HR 1.48, 95% CI 1.08, 2.02).
conclusionsMaternal CVD was associated with an increased risk of CVD in offspring during childhood and young adulthood. Paternal comparison suggests that genetic or shared familial factors may not fully explain this association.
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