Evidence map›Paper›PMID 39228316›Full record

ArticleScience progress

Impact of Morphine withdrawal on genes related to the TLR2 pathway expressed in the Prefrontal Cortex.

Bridget Truitt, Junyi Tao, Sabita Roy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bridget TruittDepartment of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Junyi TaoDepartment of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0003-2638-5386
Sabita RoyDepartment of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0002-1421-2608

Funding

Role of Microbial dysbiosis and altered metabolomics in the context of Opioid abuse and ART in HIV disease progressionR01DA043252 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2017 to 2021
$3.0M
Gut microbiota disruption by Morphine and in the context of HIV infection contributes to sustained immune activationR01DA037843 · NIDA · UNIVERSITY OF MINNESOTA · PI JOHNSON, TIMOTHY J, ROY, SABITA · 2014 to 2018
$2.8M
Microbial Dysbiosis and TLR2 Activation Contribute to Immune Activation, Inflammation and HIV Persistence in the Context of Opioid Abuse Despite ART TherapyR01DA044582 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2017 to 2021
$2.6M
Role of Gut Microbiome- Brain Axis in Modulating CNS Inflammasomes in the Neuropathology Produced by Opioid Exposure and HIV R01DA050542 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2019 to 2023
$2.5M
Role of Gut Microbiome in HIV/Opioid Induced Peripheral NeuropathyR01DA047089 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN, RAMAKRISHNAN, SUNDARAM · 2018 to 2022
$2.3M
Mechanism underlying Morphine modulation of gut barrier function in the Context oR01DA034582 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2013 to 2017
$1.6M
Multidisciplinary Training in Substance Abuse ResearchT32DA045734 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROY, SABITA · 2019 to 2023
$1.0M
NIDA NIH HHS R01 DA034582NIDA NIH HHS R01 DA037843NIDA NIH HHS R01 DA043252NIDA NIH HHS R01 DA044582NIDA NIH HHS R01 DA047089NIDA NIH HHS R01 DA050542NIDA NIH HHS T32 DA045734
6 · The paper itself

Abstract

Millions of people suffer from opioid use disorder, because of the ongoing opioid epidemic. The aversive symptoms of withdrawal are a leading factor for drug relapses, yet there are limited therapeutic options to minimize or prevent withdrawal symptoms. The mechanism behind opioid withdrawal is still not fully understood, thus preventing the development of new therapeutics. This study is an extension of our previously proposed mechanism of a toll-like receptor 2 (TLR2) mediated withdrawal response as a result of morphine induced microbial change that occurs during morphine withdrawal. Transcriptome analysis of the pre-frontal cortex indicated that there was increased expression of genes related to TLR2 signaling in morphine withdrawal treated animals compared to placebo controls. Antibiotic treatment further altered TLR2 related genes, recovering some of the morphine induced effect and leading to additional suppression of some genes related to the TLR2 pathway. Morphine withdrawal induced gene expression was attenuated in a whole body TLR2 knockout model. These results provide more support that TLR2 plays an integral role in morphine withdrawal mechanisms and could be a potential therapeutic target to minimize opioid withdrawal associated co-morbidities.

Indexed as

MorphinePrefrontal CortexSignal TransductionSubstance Withdrawal SyndromeToll-Like Receptor 2AnimalsGene Expression ProfilingGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutMorphine DependenceMorphineTlr2 protein, mouseToll-Like Receptor 2Morphinepre-frontal cortexTLR2transcriptomewithdrawal

Identifiers

PMID39228316
PMCPMC11375641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.