Evidence map›Paper›PMID 39227872›Full record

ArticleSystematic reviews2024

Antibiotic prophylaxis for the prevention of surgical site infections following colorectal surgery: protocol for network meta-analysis of randomized trials.

Shahrzad Motaghi, Francesca Mulazzani, Samer G Karam, Fatemeh Mirzayeh Fashami, Tayler Buchan, Sara Ibrahim, Shahryar Moradi Falah Langeroodi, Sahar Khademioore, Rachel J Couban, Lawrence Mbuagbaw and 2 more

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In one paragraph

Article in Systematic reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shahrzad MotaghiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. motaghis@mcmaster.ca.ORCID 0009-0008-7624-1712
Francesca MulazzaniDepartment of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Samer G KaramDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Fatemeh Mirzayeh FashamiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Tayler BuchanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Sara IbrahimDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Shahryar Moradi Falah LangeroodiCentre On Drug Policy Evaluation, MAP Centre for Urban Health Solutions, St. Michael's Hospital, Toronto, ON, Canada.
Sahar KhademiooreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Rachel J CoubanThe Michael G. DeGroote National Pain Centre, McMaster University, Hamilton, ON, Canada.
Lawrence MbuagbawDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Dominik MertzDepartment of Medicine, Division of Infectious Diseases, McMaster University, Hamilton, ON, Canada.
Mark LoebDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical site infections continue to be a significant challenge following colorectal surgery. These can result in extended hospital stays, hospital readmissions, increased treatment costs, and negative effects on patients' quality of life. Antibiotic prophylaxis plays a crucial role in preventing infection during surgery, specifically in preventing surgical site infections after colorectal surgery in adult patients. However, the optimal antibiotic regimen is still unclear based on current evidence. Considering the limitations of existing reviews, our goal is to conduct a comprehensive systematic review and network meta-analysis of randomized controlled trials to evaluate the comparative benefits and harms of available antibiotic prophylaxis regimens for preventing surgical site infections following colorectal surgery in adult patients.

methodsWe will search the Medline, EMBASE, CINAHL, Scopus, and Cochrane Central Register of Controlled Trials databases to identify relevant randomized controlled trials. We will include trials that (1) enrolled adults who underwent colorectal surgeries and (2) randomized them to any systemic administration of antibiotic (single or combined) prophylaxis before surgery compared to an alternative systemic antibiotic (single or combined antibiotic), placebo, control, or no prophylactic treatment. Pairs of reviewers will independently assess the risk of bias among eligible trials using a modified Cochrane risk of bias instrument for randomized trials. Our outcomes of interest include the rate of surgical site infection within 30 days of surgery, hospital length of stay, 30-day mortality, and treatment-related adverse effects. We will perform a contrast-based network meta-analysis using a frequentist random-effects model assuming a common heterogeneity parameter. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will be utilized to assess the certainty of evidence for treatment effects. DISCUSSION: By synthesizing evidence from available RCTs, this study will provide valuable insight for clinicians, patients, and health policymakers on the most effective antibiotics for preventing surgical site infection. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023434544.

Indexed as

Antibiotic ProphylaxisRandomized Controlled Trials as TopicSurgical Wound InfectionAnti-Bacterial AgentsColorectal SurgeryHumansNetwork Meta-Analysis as TopicSystematic Reviews as TopicAnti-Bacterial AgentsAntibiotic prophylaxisColorectal surgeryNetwork meta-analysisSurgical site infection

Identifiers

PMID39227872
PMCPMC11370109

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.