Evidence map›Paper›PMID 39227668›Full record

ArticleScientific reports2024

Heterogeneity of factors associated with cognitive decline and cortical atrophy in early- versus late-onset Alzheimer's disease.

Jaelim Cho, Cindy W Yoon, Jeong-Hyeon Shin, Haeun Seo, Woo-Ram Kim, Han Kyu Na, Justin Byun, Samuel N Lockhart, Changsoo Kim, Joon-Kyung Seong and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaelim Cho *Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Cindy W Yoon *Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea.
Jeong-Hyeon Shin *Bio Medical and Health Division, Bio Medical Research Center, Korea Testing Laboratory, Daegu, Republic of Korea.
Haeun SeoNeuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
Woo-Ram KimNeuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
Han Kyu NaDepartment of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Justin ByunDepartment of Rehabilitation Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Samuel N LockhartDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Changsoo KimDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Joon-Kyung SeongSchool of Biomedical Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. jkseong@korea.ac.kr.
Young NohNeuroscience Research Institute, Gachon University, Incheon, Republic of Korea. ynoh@gilhospital.com.

Funding

Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Gachon University Gil Medical Center FRD2022-16Ministry of Education 2021R1A6A1A03038996Ministry of Health & Welfare, Republic of Korea HI14C1135NIA NIH HHS P30 AG072947
6 · The paper itself

Abstract

The objectives of this study were to investigate the variable factors associated with cognitive function and cortical atrophy and estimated variable importance of those factors in affecting cognitive function and cortical atrophy in patients with EOAD and LOAD. Patients with EOAD (n = 40), LOAD (n = 34), and healthy volunteers with normal cognition were included (n = 65). All of them performed 3T MRI, [

Indexed as

Alzheimer DiseaseAtrophyCerebral CortexCognitive DysfunctionMagnetic Resonance ImagingNeuropsychological TestsPositron-Emission TomographyAgedAge of OnsetFemaleHumansMaleMiddle Agedtau Proteinstau ProteinsAge-at-onsetAlzheimer’s diseaseAmyloidAtrophyCerebral small vessel diseasePositron emission tomographyTauVascular risk factor

Identifiers

PMID39227668
PMCPMC11372067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.