ArticleNature communications2024
Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Characterization of BrSTM16 from Brassica rapa and functional analysis of its role in regulating cold tolerance.BMC plant biology · 2026Article
- The human DBR1 interactome reveals coupling between intron lariat turnover, pre-mRNA splicing, and RNA quality control pathways.Cell stress & chaperones · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- OsvWA36 transcriptionally regulates cell wall remodeling to control grain length in rice.BMC plant biology · 2026Article
- ZmSKIP enhances drought tolerance by reducing stomatal aperture in maize.PLoS genetics · 2026Article
- Review
- Comparative pan-genome analysis of Huperzia and Phlegmariurus and transcriptomics reveals thermal adaptation in Huperzia.Functional & integrative genomics · 2025Article
- DBR1 orchestrates the fate of lariat RNA: debranching-dependent turnover and function.Nucleic acids research · 2025Review
- Phase Separation: Orchestrating Biological Adaptations to Environmental Fluctuations.International journal of molecular sciences · 2025Review
- Molecular aspects of heat stress sensing in land plants.The Plant journal : for cell and molecular biology · 2025Review
- Stress sensing and response through biomolecular condensates in plants.Plant communications · 2025Review
- Crosstalk Between Phase-Separated Membraneless Condensates and Membrane-Bound Organelles in Cellular Function and Disease.Advances in experimental medicine and biology · 2025Review
- An integrated physiological indicator and transcriptomic analysis reveals the response of soybean buds to high-temperature stress.BMC plant biology · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
Heat stress (HS) poses a significant challenge to plant survival, necessitating sophisticated molecular mechanisms to maintain cellular homeostasis. Here, we identify SICKLE (SIC) as a key modulator of HS responses in Arabidopsis (Arabidopsis thaliana). SIC is required for the sequestration of RNA DEBRANCHING ENZYME 1 (DBR1), a rate-limiting enzyme of lariat intronic RNA (lariRNA) decay, into stress granules (SGs). The sequestration of DBR1 by SIC enhances the accumulation of lariRNAs, branched circular RNAs derived from excised introns during pre-mRNA splicing, which in turn promote the transcription of their parental genes. Our findings further demonstrate that SIC-mediated DBR1 sequestration in SGs is crucial for plant HS tolerance, as deletion of the N-terminus of SIC (SIC
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