Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Yang Yu *Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID 0009-0008-3673-5507
Xin Wang *Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, USA.ORCID 0000-0003-1456-335X
Jordan Fox *Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID 0000-0001-7171-7365
Ruofan YuDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Pilendra ThakreDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Brenna McCauleyHuffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Nicolas NikoloutsosHuffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID 0000-0002-5324-7109
Yang YuDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, USA.
Qian LiDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
P J HastingsDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Weiwei DangDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.ORCID 0000-0002-6931-4636
Kaifu ChenDepartment of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, USA. Kaifu.Chen@childrens.harvard.edu.ORCID 0000-0003-1009-4357
Grzegorz IraDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA. gira@bcm.edu.ORCID 0000-0001-5996-1138
Funding
Regulation of DNA recombination in Saccharomyces cerevisiaeR01GM080600 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI IRA, GRZEGORZ A · 2007 to 2024
$5.5M
Regulation of Initial Steps of Chromosomal Breaks RepairR01GM125650 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI IRA, GRZEGORZ A · 2018 to 2025
$2.9M
Reversal of Heart Failure: Role of Vascular RecoveryR01HL148338 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, KAIFU, COOKE, JOHN P · 2020 to 2023
$2.8M
Regulation of longevity through maintenance of transcription fidelityR01AG052507 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DANG, WEIWEI · 2017 to 2021
$2.2M
A novel role for EZH2 in A-to-I RNA editing in prostate cancerR01CA278832 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Qi Cao, Kaifu Chen · 2024 to 2026
$2.0M
Bioinformatics Techniques to Analyze Dynamic Changes of 3D GenomeR01GM138407 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CHEN, KAIFU · 2022 to 2025
$1.8M
Molecular mechanisms of cellular response to age-associated chromatin changesR01AG081347 · NIA · BAYLOR COLLEGE OF MEDICINE · PI Weiwei Dang · 2023 to 2026
$1.4M
NCI NIH HHS R01 CA278832NHLBI NIH HHS R01 HL148338NIA NIH HHS R01 AG052507NIA NIH HHS R01 AG081347NIGMS NIH HHS R01 GM080600NIGMS NIH HHS R01 GM125650NIGMS NIH HHS R01 GM138407U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM080600U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM125650
6 · The paper itself
Abstract
In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm are degraded by nucleases to prevent sterile inflammation. It remains unknown whether degradation of these DNA also prevents nuclear genome instability. We used an amplicon sequencing-based method in yeast enabling analysis of millions of DSB repair products. In non-dividing stationary phase cells, Pol4-mediated non-homologous end-joining increases, resulting in frequent insertions of 1-3 nucleotides, and insertions of mtDNA (NUMTs) or retrotransposon cDNA. Yeast EndoG (Nuc1) nuclease limits insertion of cDNA and transfer of very long mtDNA ( >10 kb) to the nucleus, where it forms unstable circles, while promoting the formation of short NUMTs (~45-200 bp). Nuc1 also regulates transfer of extranuclear DNA to nucleus in aging or meiosis. We propose that Nuc1 preserves genome stability by degrading retrotransposon cDNA and long mtDNA, while short NUMTs originate from incompletely degraded mtDNA. This work suggests that nucleases eliminating extranuclear DNA preserve genome stability.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Yeast EndoG prevents genome instability by degrading extranuclear DNA species. · full record | OpenQuestion