Evidence map›Paper›PMID 39227518›Full record

ArticleHuman cell2024

Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood-brain barrier integrity.

Yue Cao, Ruixian Xing, Qiushi Li, Yang Bai, Xuewen Liu, Buxian Tian, Xin Li

Abstract read
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In one paragraph

Article in Human cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue CaoDepartment of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Ruixian XingDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
Qiushi LiDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
Yang BaiDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
Xuewen LiuDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
Buxian TianDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China.
Xin LiDepartment of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China. lixinsci@126.com.

Funding

Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-065B
6 · The paper itself

Abstract

Reperfusion after cerebral ischemia leads to secondary damage to the nervous system, called cerebral ischemia/reperfusion injury (CIRI). The blood-brain barrier (BBB) consists of endothelial cells and tight junction (TJ) proteins, and its disruption aggravates CIRI. Two GSE datasets identified Tissue Factor Pathway Inhibitor 2 (TFPI2) as a differentially upregulated gene (Log2FC > 1, p < 0.01) in the cerebral cortex of ischemic rats, and TFPI2 affects angiogenesis of endothelial cells. Moreover, genes (c-Jun, c-Fos, FosL1) encoding subunits of Activator Protein-1 (AP-1), a transcription factor involved in IRI, were highly expressed in ischemic samples. Thus, the effects of the AP-1/TFPI2 axis on CIRI were explored. We determined increased TFPI2 expression in the cerebral cortex of rats receiving middle cerebral artery occlusion (MCAO) for 90 min and reperfusion (R) for 48 h. Then AAV2-shTFPI2 particles (5 × 10

Indexed as

Blood-Brain BarrierGlycoproteinsReperfusion InjuryTranscription Factor AP-1AnimalsBrain IschemiaDisease Models, AnimalEndothelial CellsGene ExpressionHumansMaleMiceRatsRats, Sprague-DawleyGlycoproteinstissue-factor-pathway inhibitor 2Transcription Factor AP-1Activator protein-1Blood–brain barrierCerebral ischemia/reperfusion injuryTight junctionTissue factor pathway inhibitor 2

Identifiers

PMID39227518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.