ArticleNature medicine2024
A time-stratified, case-crossover study of heat exposure and perinatal mortality from 16 hospitals in sub-Saharan Africa.
Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Aspirin and Preterm Birth Among Pregnant People With Increased Heat Exposure: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- The Impact of Ambient Heat on Perinatal and Neonatal Health in the Context of Climate Change: A Scoping Review.Current environmental health reports · 2026Article
- Intermittent exposure to high ambient heat during the second half of gestation in mice causes mild alterations of reproductive endpoints in male embryos.bioRxiv : the preprint server for biology · 2026Article
- Impact of extreme precipitation events on facility-based births in 21 sub-Saharan African countries.Nature communications · 2026Article
- Interventional applications of a Stroke Heat Risk Prediction Model produce health benefits.Nature communications · 2026Article
- Ambient temperature extremes and neonatal mortality: a time-stratified case-crossover analysis using Demographic and Health Survey data from East Africa (2011-2022).BMJ public health · 2026Article
- Association of ambient temperature with mortality in community-based patients with severe mental disorders: a time-stratified case-crossover study in western China.BMC psychiatry · 2025Article
- Scarlet fever and meteorological exposures in Jiangsu, China: a time-stratified case-crossover study.BMC public health · 2025Article
- The target trial framework in global health research: barriers and opportunities.Journal of global health · 2025Review
- Global call to understand intersectionality between heat exposure and perinatal mental health.Maternal health, neonatology and perinatology · 2025Article
- Impact of Heat on Birth Outcomes and Child Nutrition: Study Protocol using the CIDACS Birth Cohort.Wellcome open research · 2025Article
- The impact of climate change on maternal and child health outcomes in sub-Saharan Africa: A five-year (2020-2024) scoping review.The journal of climate change and healthReview
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Growing evidence suggests that extreme heat events affect both pregnant women and their infants, but few studies are available from sub-Saharan Africa. Using data from 138,015 singleton births in 16 hospitals in Benin, Malawi, Tanzania and Uganda, we investigated the association between extreme heat and early perinatal deaths, including antepartum and intrapartum stillbirths, and deaths within 24 h after birth using a time-stratified case-crossover design. We observed an association between an increase from the 75th to the 99th percentile in mean temperature 1 week (lag 0-6 d) before childbirth and perinatal mortality (odds ratio (OR) = 1.34 (95% confidence interval (CI) 1.01-1.78)). The estimates for stillbirths were similarly positive, but CIs included unity: OR = 1.29 (95% CI 0.95-1.77) for all stillbirths, OR = 1.18 (95% CI 0.71-1.95) for antepartum stillbirths and OR = 1.64 (95% CI 0.74-3.63) for intrapartum stillbirths. The cumulative exposure-response curve suggested that the steepest slopes for heat for intrapartum stillbirths and associations were stronger during the hottest seasons. We conclude that short-term heat exposure may increase mortality risks, particularly for intrapartum stillbirths, raising the importance of improved intrapartum care.
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