ArticleNature communications2024
A molecular mechanism to diversify Ca
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Article
- Selective Screening of Dual-Target Bioactive Constituents From Shaoqitongfei Formula Against Chronic Obstructive Pulmonary Disease by Receptor Chromatography.Journal of separation science · 2026Article
- PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and GαProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis.iScience · 2026Article
- Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons.Nature metabolism · 2026Article
- Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities.Molecular neurobiology · 2026Review
- Enhancement of a nuclear factor of activated T cells (NFAT) reporter for the study of G protein-coupled receptors.Communications biology · 2026Article
- PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and GαbioRxiv : the preprint server for biology · 2026Article
- Chemigenetic kinase biosensors illuminate cell signaling networks.Nature biotechnology · 2026Article
- Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule.EMBO molecular medicine · 2026Article
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
- Re-evaluating Gα protein-response element specificity in GPCR signaling.Communications biology · 2026Article
- An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum.PLoS genetics · 2026Article
- Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis.Cells · 2025Review
- Development of Mutant MBiochemistry · 2025Article
- An integrated mechanism of GProceedings of the National Academy of Sciences of the United States of America · 2025Article
- MnInternational journal of molecular sciences · 2025Article
- Arrestin-independent internalization of the GLP-1 receptor is facilitated by a GRK, clathrin, and caveolae-dependent mechanism.The FEBS journal · 2025Article
- Identification and molecular characterization of missense mutations in orphan G protein-coupled receptor GPR61 occurring in severe obesity.Molecular pharmacology · 2025Article
- Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology.Journal of cell science · 2025Review
Corrections and comments
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Authors and funding
23 authors.
Julian Brands *Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Sergi Bravo *Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.ORCID 0000-0001-5541-2860
Lars Jürgenliemke *Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.ORCID 0009-0001-2701-9276
Lukas GrätzDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6755-0742
Hannes SchihadaDepartment of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany.
Fabian FrechenInstitute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0009-0003-1279-2842
Judith AlenfelderMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.ORCID 0009-0009-3733-3443
Cy PfeilMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Paul Georg OhseMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Suzune HiratsukaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Kouki KawakamiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.ORCID 0000-0002-2507-8619
Luna C SchmackeDepartment of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany.
Nina HeyckeMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.ORCID 0000-0003-0805-4049
Gabriele KönigInstitute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Alexander PfeiferInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.ORCID 0000-0001-8805-6831
Dagmar WachtenInstitute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-4800-6332
Gunnar SchulteDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2700-7013
Torsten SteinmetzerDepartment of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany.
Val J WattsDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Drug Discovery, Purdue University, West Lafayette, IN, USA.
Jesús GomezaMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.ORCID 0000-0002-2452-8016
Katharina SimonMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Evi KostenisMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany. kostenis@uni-bonn.de.ORCID 0000-0001-8284-5514
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 214362475/GRK1873/2Deutsche Forschungsgemeinschaft (German Research Foundation) 290847012/FOR2372Deutsche Forschungsgemeinschaft (German Research Foundation) 494832089 /GRK2873Japan Agency for Medical Research and Development (AMED) JP22ama121038Japan Agency for Medical Research and Development (AMED) JP22zf0127007MEXT | Japan Science and Technology Agency (JST) 22714181MEXT | Japan Science and Technology Agency (JST) JPMJFR215TMEXT | Japan Science and Technology Agency (JST) JPMJMS2023MEXT | Japan Society for the Promotion of Science (JSPS) JP21H04791MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05037MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05113MEXT | Japan Society for the Promotion of Science (JSPS) JPJSBP120213501
Abstract
A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca
Indexed as
CalciumCalcium SignalingPhospholipase C betaReceptors, G-Protein-CoupledAdenylyl CyclasesAnimalsCRISPR-Cas SystemsCyclic AMPCytosolGene EditingGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsGTP-Binding Protein beta SubunitsHEK293 CellsHumansAdenylyl CyclasesCalciumCyclic AMPGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsGTP-Binding Protein beta SubunitsPhospholipase C betaReceptors, G-Protein-Coupled
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.