Evidence map›Paper›PMID 39227309›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

Age and visual cortex inhibition: a TMS-MRS study.

Molly Simmonite, Dalia Khammash, Katherine J Michon, Abbey Hamlin, Stephan F Taylor, Michael Vesia, Thad A Polk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Molly SimmoniteDepartment of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109, United States.ORCID 0000-0001-7181-8094
Dalia KhammashDepartment of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States.
Katherine J MichonDepartment of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States.
Abbey HamlinDepartment of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States.
Stephan F TaylorDepartment of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109, United States.
Michael VesiaSchool of Kinesiology, University of Michigan, 830 North University, Ann Arbor, MI 48109, United States.
Thad A PolkDepartment of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States.

Funding

Investigating age-related neural dedifferentiation longitudinally and in Alzheimer’s pathologyR01AG050523 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POLK, THAD A · 2016 to 2025
$5.7M
Upgrade for MRI Instrument for Functional Brain ImagingS10OD026738 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOLL, DOUGLAS C · 2019 to 2019
$1.8M
National Institute on Aging at the National Institutes of Health R01AG050523NIA NIH HHS R01 AG050523Office of Research Infrastructure Programs at the National Institutes of Health S10OD026738
6 · The paper itself

Abstract

Paired-pulse transcranial magnetic stimulation is a valuable tool for investigating inhibitory mechanisms in motor cortex. We recently demonstrated its use in measuring cortical inhibition in visual cortex, using an approach in which participants trace the size of phosphenes elicited by stimulation to occipital cortex. Here, we investigate age-related differences in primary visual cortical inhibition and the relationship between primary visual cortical inhibition and local GABA+ in the same region, estimated using magnetic resonance spectroscopy. GABA+ was estimated in 28 young (18 to 28 years) and 47 older adults (65 to 84 years); a subset (19 young, 18 older) also completed a paired-pulse transcranial magnetic stimulation session, which assessed visual cortical inhibition. The paired-pulse transcranial magnetic stimulation measure of inhibition was significantly lower in older adults. Uncorrected GABA+ in primary visual cortex was also significantly lower in older adults, while measures of GABA+ that were corrected for the tissue composition of the magnetic resonance spectroscopy voxel were unchanged with age. Furthermore, paired-pulse transcranial magnetic stimulation-measured inhibition and magnetic resonance spectroscopy-measured tissue-corrected GABA+ were significantly positively correlated. These findings are consistent with an age-related decline in cortical inhibition in visual cortex and suggest paired-pulse transcranial magnetic stimulation effects in visual cortex are driven by GABAergic mechanisms, as has been demonstrated in motor cortex.

Indexed as

Aginggamma-Aminobutyric AcidMagnetic Resonance SpectroscopyNeural InhibitionTranscranial Magnetic StimulationVisual CortexAdolescentAdultAgedAged, 80 and overFemaleHumansMaleYoung Adultgamma-Aminobutyric Acidaginggamma-aminobutyric acidmagnetic resonance spectroscopytranscranial magnetic stimulation

Identifiers

PMID39227309
PMCPMC12098002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.