Evidence map›Paper›PMID 39227273›Full record

ArticleJournal of voice : official journal of the Voice Foundation2024

Vocal Fold Injury Produces Similar Biomechanical Outcomes in Male and Female Rabbits.

Trent Sherman, Patrick Schlegel, Rodell Santuray, Zhaoyan Zhang, Jennifer L Long

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of voice : official journal of the Voice Foundation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Trent ShermanDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Patrick SchlegelDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Rodell SanturayDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Zhaoyan ZhangDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.
Jennifer L LongDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California; Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California. Electronic address: jlong@mednet.ucla.edu.

Funding

Tissue engineering to regenerate functional vocal fold after scarring or tissue lossR01DC016959 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONG, JENNIFER L · 2018 to 2022
$3.7M
Long-term function of vocal fold replacement in swineI01RX003649 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI Jennifer L Long · 2023 to 2026
–
NIDCD NIH HHS R01 DC016959RRD VA I01 RX003649
6 · The paper itself

Abstract

objectiveSex differences in response to trauma and physiologic stressors have been identified in numerous organ systems but have not yet been defined in the larynx. The objective of this study was to develop an endoscopic vocal fold injury model in rabbits and to compare structural and functional outcomes between male and female subjects. STUDY

designBasic science study.

methodsTwo male and two female rabbits underwent unilateral endoscopic cordectomy. Animals were intubated with a size 3-0 neonatal endotracheal tube, and laryngoscopy was performed with a 4 mm Hopkins rod telescope. While visualizing, a 2 mm cupped forceps grasped and resected the mid-membranous portion of the right true vocal fold. Larynges were then harvested after 8weeks. Excised larynx phonation with high-speed videography and kymography was used to assess vibrational quality. Tissue elastic (Young's) modulus was measured by indentation.

resultsInjured larynges phonated with fundamental frequencies between 237-415 Hz. In both males and females, the scarred vocal fold exhibited an increased Young's modulus compared to the contralateral nonoperated vocal fold. There were no notable differences in glottal closure pattern or vocal fold oscillation symmetry between sexes.

conclusionWe have demonstrated a model for vocal fold scarring in rabbits. Vibrational and structural outcomes were similar between the examined male and female larynges.

Indexed as

BiomechanicsScarSex differencesVocal foldWound healing

Identifiers

PMID39227273
PMCPMC13152206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.