Evidence map›Paper›PMID 39226893›Full record

ArticleThe American journal of tropical medicine and hygiene2024

Use of Comparative Genomics To Resolve an Unusual Case of Aminoglycoside Susceptibility in the Melioidosis Pathogen Burkholderia pseudomallei in Bangladesh.

Mirjam Kaestli, Saika Farook, Md Shariful Alam Jilani, Shaheda Anwar, Tanvir Ahmed Siddiqui, Mark Mayo, Yuwana Podin, Jessica R Webb, David A B Dance, Bart J Currie

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Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mirjam KaestliMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Saika FarookDepartment of Microbiology, Ibrahim Medical College, Dhaka, Bangladesh.
Md Shariful Alam JilaniDepartment of Microbiology, Ibrahim Medical College, Dhaka, Bangladesh.
Shaheda AnwarDepartment of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Tanvir Ahmed SiddiquiDepartment of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Mark MayoMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Yuwana PodinInstitute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Jessica R WebbMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
David A B DanceLao-Oxford-Mahosot Hospital-Wellcome Trust Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic.
Bart J CurrieMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melioidosis is an emerging tropical infectious disease with a rising global burden caused by the environmental bacterium Burkholderia pseudomallei. It is endemic in Southeast and South Asia, including Bangladesh. A rare aminoglycoside-susceptible B. pseudomallei isolate (Y2019) has recently been reported from a melioidosis patient in Dhaka, Bangladesh. To understand the geographical origins of Y2019, we subjected it and 10 other isolates from Bangladesh to whole-genome sequencing. In a phylogenetic tree with a global set of B. pseudomallei genomes, most Bangladeshi genomes clustered tightly within the Asian clade. In contrast, Y2019 was closely related to ST881 isolates from Sarawak, Malaysian Borneo, a gentamicin-sensitive sequence type, suggesting infection in Borneo. Y2019 also contained the same gentamicin sensitivity conferring nonsynonymous mutation in the drug efflux pump encoding the amrB gene. In the absence of a full travel history, whole-genome sequencing and bioinformatics tools have revealed the likely origin of this rare isolate.

Indexed as

Anti-Bacterial AgentsBurkholderia pseudomalleiGenomicsMelioidosisPhylogenyAminoglycosidesBangladeshDrug Resistance, BacterialGenome, BacterialHumansMicrobial Sensitivity TestsWhole Genome SequencingAminoglycosidesAnti-Bacterial Agents

Identifiers

PMID39226893
PMCPMC11542514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.