ReviewNeonatology2024
Less Invasive Surfactant Administration for Preterm Infants - State of the Art.
Review in Neonatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Overview of the Effectiveness of Different Surfactant Administration Methods: An Umbrella Review of Meta-Analyses.Pediatric pulmonology · 2026Pooled it
- Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- Can non-pharmacological comfort care replace fentanyl in LISA? The NONA-LISA feasibility study.Pediatric research · 2026Trial
- Neonatal Postresuscitation Care in Brazil: A National Overview.American journal of perinatology · 2026Article
- Pain Assessment During Less Invasive Surfactant Administration Using Skin Conductance: A Prospective Cohort Study.Pediatric research · 2026Observational
- Surfactant administration in late preterm and term neonates: is LISA ready for routine use?European journal of pediatrics · 2026Review
- Lung Ultrasound-Guided Surfactant Therapy in Neonatal Pneumothorax and Pulmonary Hemorrhage: Pathophysiology, Diagnostic Ultrasonography, and Emerging Clinical Approaches.Children (Basel, Switzerland) · 2026Review
- Fiberscope-Assisted Surfactant Therapy (FAST) in Neonatal Respiratory Distress Syndrome: Four-Year Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Lung Function Trajectories After Preterm Birth: A Life-Course Approach to Age-Specific Monitoring.Children (Basel, Switzerland) · 2026Review
- Vikings, LISA and pain killers….Pediatric research · 2026Article
- Dexmedetomidine for LISA procedure: a prospective observational single center experience.Italian journal of pediatrics · 2026Observational
- Take a deep breath: the important role of vitamin A in neonatal lung development and visiting the potential of aerosolized delivery for bronchopulmonary dysplasia prevention.Expert review of respiratory medicine · 2026Article
- Rising rates of non-invasive ventilation and bronchopulmonary dysplasia: A propensity score-matched analysis.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Non-Invasive Surfactant Administration in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Structured continuous positive airway pressure weaning standardizes discontinuation and reduces instability events.Frontiers in pediatrics · 2026Article
- Lipidomic signatures of tracheal aspirate diagnostic biomarkers in preterm infants with bronchopulmonary dysplasia.European journal of pediatrics · 2025Article
- Predicting Surfactant Need at Birth: Failed Validation of a Bedside Method Using Gastric Aspirates.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Impact of LISA failure on 2-year neurodevelopmental outcomes in preterm infants: a retrospective cohort study.BMJ paediatrics open · 2025Article
- Surfactant treatment rate in very premature infants following change to less-invasive surfactant administration.European journal of pediatrics · 2025Observational
- Lung Surfactant Deficiency in Severe Respiratory Failure: A Potential Biomarker for Clinical Assessment.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLess invasive surfactant administration (LISA) has become the preferred method of surfactant administration for spontaneously breathing babies on continuous positive airway pressure (CPAP). SUMMARY: The development of LISA followed the need to combine CPAP and surfactant replacement as mainstay treatment options for respiratory distress syndrome, thereby avoided exposure to positive pressure ventilation. KEY MESSAGES: This review summarises the current knowns and unknowns of LISA including the physiological concept, its relevance for short-term and long-term outcomes and the challenges for practical implementation of LISA as part of a less invasive respiratory care bundle. Further, we provide an update of the evidence on alternatives to LISA, for example, nebulised surfactant administration, pharyngeal deposition of surfactant and delivery via supraglottic airway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.