Evidence map›Paper›PMID 39226841›Full record

ArticleCell calcium2024

Unveiling the intricate role of S100A1 in regulating RyR1 activity: A commentary on "Structural insights into the regulation of RyR1 by S100A1".

Megan L Perry, Kristen M Varney, Pratyush Tiwary, David J Weber, Erick O Hernández-Ochoa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan L PerryDepartment of Biochemistry & Molecular Biology School of Medicine University of Maryland, Baltimore, MD, USA.
Kristen M VarneyDepartment of Biochemistry & Molecular Biology School of Medicine University of Maryland, Baltimore, MD, USA; Center for Biomolecular Therapeutics (CBT), Baltimore, MD, USA; Institute of Bioscience and Biotechnology Research (IBBR), Rockville, MD, USA.
Pratyush TiwaryDepartment of Biochemistry & Molecular Biology School of Medicine University of Maryland, Baltimore, MD, USA; Department of Chemistry & Biochemistry and Institute for Physical Science & Technology, University of Maryland, College Park, MD, USA; University of Maryland Institute for Health Computing, Bethesda, MD 20852, USA.
David J WeberDepartment of Biochemistry & Molecular Biology School of Medicine University of Maryland, Baltimore, MD, USA; Center for Biomolecular Therapeutics (CBT), Baltimore, MD, USA; Institute of Bioscience and Biotechnology Research (IBBR), Rockville, MD, USA; Department of Chemistry & Biochemistry and Institute for Physical Science & Technology, University of Maryland, College Park, MD, USA.
Erick O Hernández-OchoaDepartment of Biochemistry & Molecular Biology School of Medicine University of Maryland, Baltimore, MD, USA. Electronic address: ehernandez-ochoa@som.umaryland.edu.

Funding

Supplement to promote diversity: From atoms to mechanisms - Artificial Intelligence augmented molecular simulations for mechanistic ligand design.R35GM142719 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI TIWARY, PRATYUSH · 2021 to 2025
$2.0M
Rad and amyotrophic lateral sclerosis (ALS)R01NS103777 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HERNANDEZ-OCHOA, ERICK OMAR · 2018 to 2022
$1.7M
Voltage sensor domain movements in skeletal muscle fiber activationR01AR075726 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2021 to 2025
$1.7M
Signal Propagation in Protein Allostery: Mechanism and EvolutionR01GM129327 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WEBER, DAVID JOSEPH · 2019 to 2022
$1.3M
NIAMS NIH HHS R01 AR075726NIGMS NIH HHS R01 GM129327NIGMS NIH HHS R35 GM142719NINDS NIH HHS R01 NS103777
6 · The paper itself

Abstract

S100A1, a calcium-binding protein, plays a crucial role in regulating Ca

Indexed as

Ryanodine Receptor Calcium Release ChannelS100 ProteinsAnimalsCalciumCalmodulinHumansCalciumCalmodulinRyanodine Receptor Calcium Release ChannelS100A1 proteinS100 ProteinsCalcium releaseCaMCa(V)1.1Cryo-EMmodulationMuscle contractionRyR1S100A1

Identifiers

PMID39226841
PMCPMC11613144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.