Evidence map›Paper›PMID 39226817›Full record

ReviewCurrent opinion in microbiology2024

The yin and yang of the universal transcription factor NusG.

Madeleine Delbeau, Ruby Froom, Robert Landick, Seth A Darst, Elizabeth A Campbell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madeleine DelbeauLaboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY 10065, USA.
Ruby FroomLaboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY 10065, USA.
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Elizabeth A CampbellLaboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY 10065, USA. Electronic address: campbee@rockefeller.edu.

Funding

STRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2M
Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
Structural and functional studies of the mycobacterial transcription cycleR35GM151879 · NIGMS · ROCKEFELLER UNIVERSITY · PI ELIZABETH A CAMPBELL · 2024 to 2026
$1.4M
NIGMS NIH HHS R01 GM038660NIGMS NIH HHS R35 GM118130NIGMS NIH HHS R35 GM151879
6 · The paper itself

Abstract

RNA polymerase (RNAP), the central enzyme of transcription, intermittently pauses during the elongation stage of RNA synthesis. Pausing provides an opportunity for regulatory events such as nascent RNA folding or the recruitment of transregulators. NusG (Spt5 in eukaryotes and archaea) regulates RNAP pausing and is the only transcription factor conserved across all cellular life. NusG is a multifunctional protein: its N-terminal domain (NGN) binds to RNAP, and its C-terminal KOW domain in bacteria interacts with transcription regulators such as ribosomes and termination factors. In Escherichia coli, NusG acts as an antipausing factor. However, recent studies have revealed that NusG has distinct transcriptional regulatory roles specific to bacterial clades with clinical implications. Here, we focus on NusG's dual roles in the regulation of pausing.

Indexed as

Escherichia coliEscherichia coli ProteinsPeptide Elongation FactorsBacteriaDNA-Directed RNA PolymerasesGene Expression Regulation, BacterialTranscriptional Elongation FactorsTranscription FactorsTranscription, GeneticDNA-Directed RNA PolymerasesEscherichia coli ProteinsNusG protein, E coliPeptide Elongation FactorsTranscriptional Elongation FactorsTranscription Factors

Identifiers

PMID39226817
PMCPMC11421859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.