Evidence map›Paper›PMID 39226717›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2024

Ultra-processed products and risk of liver cancer: A prospective cohort study.

Longgang Zhao, Xinyuan Zhang, Danxia Yu, Lei Wang, Martha J Shrubsole, Wei Zheng, Staci L Sudenga, Xuehong Zhang

Abstract read
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Longgang ZhaoSchool of Nursing, Yale University, Orange, CT, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Xinyuan ZhangChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Danxia YuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lei WangDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Martha J ShrubsoleDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Staci L SudengaDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Xuehong ZhangSchool of Nursing, Yale University, Orange, CT, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: xuehong.zhang@yale.edu.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Decoding mechanisms underlying metabolic dysregulation in obesity and digestive cancer riskU01CA272452 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIOVANNUCCI, EDWARD, TOBIAS, DEIRDRE KAY · 2022 to 2025
$6.4M
Perfluoroalkyl Substances (PFASs) and Liver Cancer Risk in the United StatesU01CA259208 · NCI · YALE UNIVERSITY · PI ZHANG, XUEHONG · 2022 to 2025
$2.9M
Helicobacter Infection and Liver Cancer Risk among African Americans andWhites in the United StatesR37CA262299 · NCI · YALE UNIVERSITY · PI Xuehong Zhang · 2021 to 2026
$2.4M
Tumor-Infiltrating Lymphocytes in Anal Cancer and Pre-malignant Anal LesionsK07CA225404 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SUDENGA, STACI L · 2018 to 2022
$742k
Multidisciplinary Study of Folate Intake and Colorectal CancerR21CA252962 · NCI · YALE UNIVERSITY · PI ZHANG, XUEHONG · 2021 to 2022
$487k
Proteomics Study of Non-viral Related Hepatocellular Carcinoma RiskR21CA238651 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, XUEHONG · 2020 to 2021
$477k
NCI NIH HHS K07 CA225404NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA092447NCI NIH HHS R21 CA238651NCI NIH HHS R21 CA252962NCI NIH HHS R37 CA262299NCI NIH HHS U01 CA202979NCI NIH HHS U01 CA259208NCI NIH HHS U01 CA272452NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

BACKGROUND &

aimsSeveral studies have shown positive associations between ultra-processed foods and drinks and cancer risk. However, evidence remains limited for liver cancer. We aimed to evaluate the associations between ultra-processed foods and drinks and liver cancer risk.

methodsWe included 73,119 participants (22,431 Whites, 47,837 Blacks, 2851 other race) from the Southern Community Cohort Study. Ultra-processed products were defined based on the Nova classification using data from a validated food frequency questionnaire and calculated as percentage of daily foods by weight. Incident liver cancer and vital status were ascertained via linkages to state cancer registries and the National Death Index as of December 31, 2019.

resultsWith a median of 13.9 year's follow-up, we documented 453 incident liver cancer cases. Participants with higher intake of ultra-processed foods had an elevated risk of liver cancer (hazard ratios [HR] DISCUSSION: In a prospective cohort with predominantly low-income Southern US adults, we found certain ultra-processed foods were associated with a higher risk of liver cancer. Further studies are needed to confirm our findings.

Indexed as

Fast FoodsLiver NeoplasmsAdultAgedCohort StudiesDietFemaleFood HandlingHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsBeveragesCohortLiver cancerProcessed grainsProcessed protein foodsUltra-processed foods

Identifiers

PMID39226717
PMCPMC11479389

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.