Evidence map›Paper›PMID 39226584›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Somatostatin peptides prevent increased human colonic epithelial permeability induced by hypoxia.

Ibrahim Rajput, Vazhaikkurichi M Rajendran, Andrew J Nickerson, J Peter A Lodge, Geoffrey I Sandle

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ibrahim RajputDepartment of Surgery, St James's University Hospital, Leeds, United Kingdom.
Vazhaikkurichi M RajendranDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, West Virginia, United States.ORCID 0000-0002-8999-8721
Andrew J NickersonDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, West Virginia, United States.ORCID 0000-0001-7604-2344
J Peter A LodgeDepartment of Surgery, St James's University Hospital, Leeds, United Kingdom.
Geoffrey I SandleLeeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, United Kingdom.ORCID 0000-0002-6956-4168

Funding

Role of IK channels in rat distal colonR01DK018777 · NIDDK · YALE UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 1986 to 2010
$2.5M
Role of BK Channels in K+-driven Colonic Water Secretion in Health and DiseaseR01DK104791 · NIDDK · WEST VIRGINIA UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 2015 to 2019
$1.7M
Aldosterone Activation of Trans-epithelial Iron Absorption in Human ColonR21DK112085 · NIDDK · WEST VIRGINIA UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 2018 to 2019
$404k
NIDDK NIH HHS R01 DK018777NIDDK NIH HHS R01 DK104791NIDDK NIH HHS R21 DK112085
6 · The paper itself

Abstract

Mesenteric ischemia increases gut permeability and bacterial translocation. In human colon, chemical hypoxia induced by 2,4-dinitrophenol (DNP) activates basolateral intermediate conductance K

Indexed as

ColonHypoxiaIntestinal MucosaOctreotidePermeabilitySomatostatinAgedAnimalsFemaleHumansMaleMiddle AgedRatsRats, Sprague-DawleyOctreotideSomatostatincolonic permeabilitymesenteric ischemiaparacellular conductancepotassium channelssomatostatin peptides

Identifiers

PMID39226584
PMCPMC11559641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.