Evidence map›Paper›PMID 39226517›Full record

ArticleNeurology2024

Association Between Postsurgical Functional Connectivity and Seizure Outcome in Patients With Temporal Lobe Epilepsy.

Behnaz Akbarian, Lucas E Sainburg, Andrew Janson, Graham Johnson, Derek J Doss, Baxter P Rogers, Dario J Englot, Victoria L Morgan

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In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Behnaz AkbarianFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2016-8201
Lucas E SainburgFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Andrew JansonFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-6552-4011
Graham JohnsonFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Derek J DossFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2685-0762
Baxter P RogersFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-5666-2797
Dario J EnglotFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8373-690X
Victoria L MorganFrom the Department of Biomedical Engineering (B.A., L.E.S., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Vanderbilt University; and Vanderbilt University Institute of Imaging Science (B.A., L.E.S., A.J., G.J., D.J.D., B.P.R., D.J.E., V.L.M.), Department of Radiology and Radiological Sciences, and Department of Neurological Surgery (D.J.E., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-8263-2324

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
The Role of Network Connectivity in Post-Surgical Seizure Recurrence in Temporal Lobe EpilepsyR01NS110130 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2018 to 2023
$2.5M
MRI Connectivity Biomarkers of Treatment Response in Focal EpilepsyR01NS108445 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2019 to 2024
$2.5M
MRI Structural and Functional Connectivity Changes in Temporal Lobe EpilepsyR01NS075270 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2012 to 2016
$1.7M
Temporal Clustering Analysis for Detection of Irregular Transient fMRI ActivationR01NS055822 · NINDS · VANDERBILT UNIVERSITY · PI MORGAN, VICTORIA L · 2007 to 2009
$806k
Seizure onset zone localization with functional MRI correlates of interictal physiology in temporal lobe epilepsyF31NS135908 · NINDS · VANDERBILT UNIVERSITY · PI SAINBURG, LUCAS · 2024 to 2025
$87k
NIBIB NIH HHS T32 EB001628NICHD NIH HHS P50 HD103537NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NINDS NIH HHS F31 NS135908NINDS NIH HHS R01 NS055822NINDS NIH HHS R01 NS075270NINDS NIH HHS R01 NS108445NINDS NIH HHS R01 NS110130
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDespite the success of presurgical network connectivity studies in predicting short-term (1-year) seizure outcomes, later seizure recurrence occurs in some patients with temporal lobe epilepsy (TLE). To uncover contributors to this recurrence, we investigated the relationship between functional connectivity and seizure outcomes at different time points after surgery in these patients.

methodsPatients included were clinically diagnosed with unilateral mesial TLE after a standard clinical evaluation and underwent selective amygdalohippocampectomy. Healthy controls had no history of seizures or head injury. Using resting-state fMRI, we assessed the postsurgical functional connectivity node strength, computed as the node's total strength to all other nodes, between seizure-free (Engel Ia-Ib) and nonseizure-free (Engel Ic-IV) acquisitions. The change over time after surgery in different outcome groups in these nodes was also characterized.

resultsPatients with TLE (n = 32, mean age: 43.1 ± 11.9 years; 46.8% female) and 85 healthy controls (mean age: 37.7 ± 13.5 years; 48.2% female) were included. Resting fMRI was acquired before surgery and at least once after surgery in each patient (range 1-4 scans, 5-60 months). Differences between patients with (n = 30) and without (n = 18) seizure freedom were detected in the posterior insula ipsilateral to the resection (I-PIns: 95% CI -154.8 to -50.1, DISCUSSION: The findings suggest that network evolution in the first 5 years after selective amygdalohippocampectomy surgery is related to seizure outcomes in TLE. This highlights the need to identify presurgical and surgical conditions that lead to disparate postsurgical trajectories between seizure-free and nonseizure-free patients to identify potential contributors to long-term seizure outcomes. However, the lack of including other surgical approaches may affect the generalizability of the results.

Indexed as

Epilepsy, Temporal LobeMagnetic Resonance ImagingSeizuresAdultAmygdalaFemaleHippocampusHumansMaleMiddle AgedTreatment Outcome

Identifiers

PMID39226517
PMCPMC11373675

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.