ArticlePLoS biology2024
The coral pathogen Vibrio coralliilyticus uses a T6SS to secrete a group of novel anti-eukaryotic effectors that contribute to virulence.
Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.Gut microbes · 2026Review
- Toxin Secretion Systems Used by Marine Pathogenic Bacteria: A Review.Journal of fish diseases · 2026Review
- Review
- Deciphering the pangenome of the shellfish pathogenMicrobial genomics · 2026Article
- The type VI secretion system and associated effector proteins.Nature reviews. Microbiology · 2026Review
- Absence of conserved immune signalling pathways and increased pathogen susceptibility associated to photosymbiosis in acoels.BMC biology · 2026Article
- Type VI secretion systems at the interface between bacteria and eukaryotic cells.Genetics and molecular biology · 2026Article
- Temperate and filamentous bacteriophages as reservoirs of bacterial virulence in stony coral tissue loss disease.Coral reefs (Online) · 2026Article
- The Coral Host Microbiome Modulates the Virulence of the Bacterial Pathogen Vibrio coralliilyticus.Environmental microbiology · 2026Article
- Genomic Features of Antimicrobial Resistance and Virulence in Multidrug-ResistantVeterinary sciences · 2025Article
- Complete genome sequences ofMicrobiology resource announcements · 2025Article
- The Competitive Edge: T6SS-Mediated Interference Competition byMicroorganisms · 2025Review
- Host-Associated Biofilms:Microorganisms · 2025Review
- A mutualistic model bacterium is lethal to non-symbiotic hosts via the type VI secretion system.mBio · 2025Article
- Assessing toxicity and competitive fitness ofmSphere · 2025Article
- A new class of type VI secretion system effectors can carry two toxic domains and are recognized through the WHIX motif for export.PLoS biology · 2025Article
- Quorum sensing regulates virulence factors in the coral pathogenApplied and environmental microbiology · 2025Article
- Distribution of the four type VI secretion systems in Pseudomonas aeruginosa and classification of their core and accessory effectors.Nature communications · 2025Article
- Halobacteriovorax halts disease progression in endangered Caribbean corals.The ISME journal · 2025Article
- High temperatures increase the virulence of Vibrio bacteria towards their coral host and competing bacteria via type VI secretion systems.PLoS biology · 2024Article
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Abstract
Vibrio coralliilyticus is a pathogen of coral and shellfish, leading to devastating economic and ecological consequences worldwide. Although rising ocean temperatures correlate with increased V. coralliilyticus pathogenicity, the specific molecular mechanisms and determinants contributing to virulence remain poorly understood. Here, we systematically analyzed the type VI secretion system (T6SS), a contact-dependent toxin delivery apparatus, in V. coralliilyticus. We identified 2 omnipresent T6SSs that are activated at temperatures in which V. coralliilyticus becomes virulent; T6SS1 is an antibacterial system mediating interbacterial competition, whereas T6SS2 mediates anti-eukaryotic toxicity and contributes to mortality during infection of an aquatic model organism, Artemia salina. Using comparative proteomics, we identified the T6SS1 and T6SS2 toxin arsenals of 3 V. coralliilyticus strains with distinct disease etiologies. Remarkably, T6SS2 secretes at least 9 novel anti-eukaryotic toxins comprising core and accessory repertoires. We propose that T6SSs differently contribute to V. coralliilyticus's virulence: T6SS2 plays a direct role by targeting the host, while T6SS1 plays an indirect role by eliminating competitors.
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