Evidence map›Paper›PMID 39226224›Full record

ArticleFEBS open bio2024

The separation between mRNA-ends is more variable than expected.

Nancy Gerling, J Alfredo Mendez, Eduardo Gomez, Jaime Ruiz-Garcia

Abstract read
In one paragraph

Article in FEBS open bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nancy GerlingInstitute of Physics, Biological Physics Laboratory, San Luis Potosi, Mexico.ORCID https://orcid.org/0000-0001-8079-4493
J Alfredo MendezInstitute of Physics, Laboratory of Molecular Biophysics, San Luis Potosi, Mexico.ORCID https://orcid.org/0000-0002-2859-7086
Eduardo GomezCold Atoms Laboratory, Institute of Physics, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Jaime Ruiz-GarciaInstitute of Physics, Biological Physics Laboratory, San Luis Potosi, Mexico.ORCID https://orcid.org/0000-0003-3730-3825

Funding

Consejo Nacional de Ciencia y Tecnología CB-237439Consejo Nacional de Ciencia y Tecnología CB-254460Consejo Nacional de Ciencia y Tecnología CB-254981Consejo Nacional de Ciencia y Tecnología FC-157Consejo Nacional de Ciencia y Tecnología FC-341
6 · The paper itself

Abstract

Effective circularization of mRNA molecules is a key step for the efficient initiation of translation. Research has shown that the intrinsic separation of the ends of mRNA molecules is rather small, suggesting that intramolecular arrangements could provide this effective circularization. Considering that the innate proximity of RNA ends might have important unknown biological implications, we aimed to determine whether the close proximity of the ends of mRNA molecules is a conserved feature across organisms and gain further insights into the functional effects of the proximity of RNA ends. To do so, we studied the secondary structure of 274 full native mRNA molecules from 17 different organisms to calculate the contour length (C

Indexed as

Nucleic Acid ConformationRNA, MessengerAnimalsHumansRNA, Messengercontour lengthmRNAphenotypic stabilityRNA external loopRNA secondary structure

Identifiers

PMID39226224
PMCPMC11609591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.