Evidence map›Paper›PMID 39225956›Full record

SynthesisJournal of neuro-oncology2024

The effect of depression and anxiety on survival in patients with glioma: a systematic review and meta-analysis.

Jiahan Dong, Qiannan Chen, Shimeng Weng, Lingyu Liu, Jiangwei Wang, Shengyu Fang, Xing Fan, Tao Jiang

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07409584 (Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07409584 recruitingnot on this mapstarted 2026, after this paper: background citation

Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study (SHINE-GLIO Study)

TypeobservationalSponsorUniversity Hospital, EssenRan2026 to 2028Enrolled180ConditionsGlioblastoma (GBM)ArmsMedical history, physical examination, completing questionnaires, data collection
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiahan DongBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Qiannan ChenBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Shimeng WengBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Lingyu LiuBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jiangwei WangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Shengyu FangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China. fangtuo1@aliyun.com.
Xing FanBeijing Neurosurgical Institute, Capital Medical University, Beijing, China. xingkongyaoxiang@163.com.
Tao JiangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China. taojiang1964@163.com.ORCID http://orcid.org/0000-0002-7008-6351

Funding

The National Key Research and Development Program of China 2019YFE0109400
6 · The paper itself

Abstract

purposeDepression and anxiety's impact on glioma patient survival lacks consensus. Understanding these effects can highlight the importance of identifying depression and anxiety in glioma patients, and inform future treatments. This systematic review and meta-analysis aims to clarify the impact of depression and anxiety on glioma patient survival.

methodsWe conducted a systematic literature search of major databases, including PubMed, Embase, Web of Science Core Collection, Cochrane Library, and PsycINFO, from inception to June 2023, to identify relevant studies. Eligible studies were those that examined the association between depression, anxiety, or both, and survival outcomes in glioma patients. Data were extracted and analyzed using fixed-effects meta-analysis models to calculate pooled hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsA total of 15 studies met the inclusion criteria, encompassing a diverse range of glioma patients across different clinical settings and stages. The meta-analysis revealed a statistically significant association between depression and reduced overall survival in glioma patients, with a pooled HR of 1.65 (95% CI: 1.41-1.83, 11 studies). The preliminary univariate meta-regression results indicate no impact of individual study characteristics on the effect size. Likewise, anxiety was associated with worse overall survival, with a pooled HR of 1.65 (95% CI: 1.18-2.31, 5 studies).

conclusionsThis meta-analysis underscores the vital need to identify and treat depression and anxiety in glioma patients. Future research should explore the underlying mechanisms, aiding the creation of interventions enhancing both mental health and clinical outcomes for this vulnerable group.

Indexed as

AnxietyBrain NeoplasmsDepressionGliomaHumansPrognosisSurvival RateAnxietyDepressionGliomaMeta-analysisSurvivalSystematic review

Identifiers

PMID39225956

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.