Evidence map›Paper›PMID 39225946›Full record

Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2024

Comparative evaluation of cranberry extract and sodium fluoride as mouth rinses on S. mutans counts in children: a double-blind randomized controlled trial.

K Bansal, A Shamoo, S Mohapatra, M Kalaivani, P Batra, V P Mathur, A Srivastava, R Chaudhry

Abstract readEquivalence TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The effect of fruit extracts containing phenolic compounds on the survivability of Streptococcus mutans: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

K BansalDepartment of Pediatric & Preventive Dentistry, Centre for Dental Education & Research, All India Institute of Medical Sciences, New Delhi, India. drkalpanabansal@gmail.com.ORCID http://orcid.org/0000-0003-4503-5234
A ShamooDepartment of Pediatric & Preventive Dentistry, Centre for Dental Education & Research, All India Institute of Medical Sciences, New Delhi, India.
S MohapatraDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
M KalaivaniDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
P BatraDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-1671-7298
V P MathurDepartment of Pediatric & Preventive Dentistry, Centre for Dental Education & Research, All India Institute of Medical Sciences, New Delhi, India.
A SrivastavaDepartment of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
R ChaudhryDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Funding

Indian Council of Medical Research 2019-0972
6 · The paper itself

Abstract

backgroundRecently, research in the field of caries prevention is emphasizing upon identification of edible non-toxic compounds that can interfere with the formation of cariogenic biofilm.

aimThis trial aimed to assess the effectiveness of non-dialyzable material (NDM) containing cranberry mouth rinse (C-MR) on the Streptococcus mutans (S. mutans) counts and compare with that of a sodium fluoride (F-MR) mouth rinse.

methods280 children (8-12 years old) were enrolled in this double-blind single center, parallel, one-month, IRB/IEC approved non-inferiority trial. The participants fulfilling the inclusion criteria were randomly allocated into one of the two groups: C-MR and F-MR. All participants were given verbal and written instructions about at-home mouth-rinsing regimen under parental supervision for a month. Dental plaque samples were collected before and after a month of mouth-rinsing and subjected to culture techniques. S. mutans counts were assessed and compared in both groups. Primary outcome was the difference in the S. mutans counts between two interventions. Both intention-to-treat (ITT) and per-protocol analysis were carried out using two-sample t test with equal variance.

resultsThe mean S. mutans counts (after log transformation) in C-MR group were: 14.66 (90% CI 14.4,14.9) at baseline and 12.85 (90% CI 12.5, 13.2) colony-forming units/ml (CFU/ml) at one-month post intervention (p = 0.001); while these counts were 14.69 (90% CI 14.5, 14.9) at baseline and 12.71 (90% CI 12.3, 13.1) at one-month intervention in F-MR groups (p = 0.001). ITT analysis showed an inter- group difference of 0.14 CFU/ml (90% CI - 0.32,0.59) in post-SM counts between groups (p = 0.629).

conclusionThe study demonstrated that the cranberry mouth rinse was non-inferior to the fluoride mouth rinse in terms of S. mutans levels change. Cranberry-based mouth rinse can be used effectively to reduce the S. mutans counts in children.

trial registrationRegistration number in case of Clinical Trials-CTRI/2019/05/019395.

Indexed as

Cariostatic AgentsMouthwashesPlant ExtractsSodium FluorideStreptococcus mutansVaccinium macrocarponBacterial LoadChildDental CariesDental PlaqueDouble-Blind MethodFemaleHumansMaleCariostatic AgentsMouthwashesPlant ExtractsSodium FluorideCranberryFluorideMouth rinseNon-dialyzable materialStreptococcus mutans counts

Identifiers

PMID39225946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.