Evidence map›Paper›PMID 39225902›Full record

ReviewCell biochemistry and biophysics2024

Exosomal Non-coding RNA Derived from Mesenchymal Stem Cells (MSCs) in Autoimmune Diseases Progression and Therapy; an Updated Review.

Shireen Hamid Farhan, Saade Abdalkareem Jasim, Pooja Bansal, Harpreet Kaur, Mohammed Abed Jawad, Maytham T Qasim, Abeer Mhussan Jabbar, Mahamedha Deorari, Ahmed Alawadi, Ali Hadi

Abstract readReview
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In one paragraph

Review in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shireen Hamid FarhanBiotechnology department, College of Applied Science, Fallujah University, Fallujah, Iraq.
Saade Abdalkareem JasimMedical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. Saad.A.J.Anbar@gmail.com.
Pooja BansalDepartment of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka, India.
Harpreet KaurSchool of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, India.
Mohammed Abed JawadDepartment of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq. mohammed.a.medical.lab@nuc.edu.iq.
Maytham T QasimCollege of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.
Abeer Mhussan JabbarCollege of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq. abeer.m.jabbar@nust.edu.iq.
Mahamedha DeorariUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
Ahmed AlawadiCollege of technical engineering, the Islamic University, Najaf, Iraq.
Ali HadiDepartment of medical laboratories techniques, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation and autoimmune diseases (AD) are common outcomes of an overactive immune system. Inflammation occurs due to the immune system reacting to damaging stimuli. Exosomes are being recognized as an advanced therapeutic approach for addressing an overactive immune system, positioning them as a promising option for treating AD. Mesenchymal stem cells (MSCs) release exosomes that have strong immunomodulatory effects, influenced by their cell of origin. MSCs-exosomes, being a cell-free therapy, exhibit less toxicity and provoke a diminished immune response compared to cell-based therapies. Exosomal non-coding RNAs (ncRNA), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are intricately linked to various biological and functional aspects of human health. Exosomal ncRNAs can lead to tissue malfunction, aging, and illnesses when they experience tissue-specific alterations as a result of various internal or external problems. In this study, we will examine current trends in exosomal ncRNA researches regarding AD. Then, therapeutic uses of MSCs-exosomal ncRNA will be outlined, with a particle focus on the underlying molecular mechanisms.

Indexed as

Autoimmune DiseasesExosomesMesenchymal Stem CellsMicroRNAsRNA, Long NoncodingAnimalsHumansMicroRNAsRNA, Long NoncodingAutoimmune diseasesLong non-coding RNAsMesenchymal stem cellsMicroRNAsNon-coding RNAs

Identifiers

PMID39225902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.