Evidence map›Paper›PMID 39225891›Full record

Trial reportAIDS and behavior2024

Developmental Trajectories of Transactional Sex and Age-Disparate Relationships During Adolescence: An HPTN 068 Analysis.

Nivedita L Bhushan, Katherine B Rucinski, Marie C D Stoner, Stephanie M DeLong, F X Gómez-Olivé, Kathleen Khan, Rhian Twine, Sheree R Schwartz, Audrey E Pettifor

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nivedita L BhushanCenter for Communication and Engagement Research, RTI International, Research Triangle Park, NC, USA. nbhushan@rti.org.ORCID http://orcid.org/0000-0002-3417-3263
Katherine B RucinskiDepartment of International Health, Johns Hopkins University, Baltimore, MD, USA.
Marie C D StonerWomen's Global Health Imperative, RTI International, Berkeley, CA, USA.
Stephanie M DeLongDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
F X Gómez-OlivéMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
Kathleen KhanMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
Rhian TwineMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
Sheree R SchwartzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Audrey E PettiforDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
Effects of Cash Transfer and Community Mobilization in Young South African WomenR01MH087118 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PETTIFOR, AUDREY · 2009 to 2013
$2.5M
Implementation Research to Optimize ART Delivery for Adolescents and Young Adults Living with HIVK01MH129226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Katherine B Rucinski · 2022 to 2026
$792k
Stress and HIV infection in South African adolescent girls.R21HD106583 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI STONER, MARIE · 2021 to 2022
$436k
NIAID NIH HHS P30 AI094189NIAID NIH HHS T32 AI102623NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068619NICHD NIH HHS P2C HD050924NICHD NIH HHS R21 HD106583NICHD NIH HHS R24 HD050924NIMH NIH HHS K01 MH129226NIMH NIH HHS K01MH129226NIMH NIH HHS R01 MH087118NIMH NIH HHS R01MH087118NIMH NIH HHS R21HD106583NIMH NIH HHS T32 AI00700140NIMH NIH HHS T32 AI102623
6 · The paper itself

Abstract

Transactional sex and sexual relationships with older partners increase HIV risk in adolescent girls and young women (AGYW), yet little is known about how these behaviors co-evolve over time. We characterize temporal patterns of transactional sex and age-disparate relationships among AGYW in South Africa. Longitudinal data are from a randomized controlled trial (HPTN 068) of school-aged, HIV-negative, AGYW who attended ≥ 3 study visits. We used group-based trajectory modeling to identify trajectories of transactional sex and age-disparate relationships (partner ≥ 5 years older) in the last year and assessed the interrelationship (conditional probability) between both trajectories. At baseline, median age was 14 years, 14.5% of girls were sexually active, and transactional sex (2.1%) and age-disparate relationships were uncommon (2.7%). We identified two trajectories for transactional sex ("low" [81.9%] and "increasing" [18.1%]) and two for age-disparate relationships ("low" [91.7%] and "increasing" [8.3%]). In a separate joint trajectory analysis, nearly a third (28%) had increasing trajectories for both transactional sex and age-disparate relationships, but most (53%) had a low trajectory of both outcomes. Baseline reporting of early sexual debut, depression, and inequitable gender norms were highest in the increasing transactional sex group. Prior pregnancy, early sexual debut, and IPV were highest among those with increasing age-disparate relationships. AGYW who engage in transactional sex or age-disparate partnerships in early adolescence are more likely to experience sustained engagement in both behaviors as they transition to adulthood, increasing HIV risk. Engaging girls early may maximize effectiveness of behavioral and biomedical HIV prevention efforts.

Indexed as

Adolescent BehaviorSexual BehaviorSexual PartnersAdolescentAge FactorsFemaleHIV InfectionsHumansLongitudinal StudiesMaleRisk-TakingSex WorkSouth AfricaYoung AdultAdolescents; age-disparate PartnershipsDevelopmental TrajectoriesHIVTransactional sex

Identifiers

PMID39225891
PMCPMC12208780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.