Evidence map›Paper›PMID 39225717›Full record

ArticleAbdominal radiology (New York)2025

Bi-phase CT radiomics nomogram for the preoperative prediction of pylorus lymph node metastasis in non-pyloric gastric cancer patients.

Hao-Yu Zhang, Muerzhate Aimaiti, Long Bai, Meng-Qing Yuan, Chun-Chao Zhu, Jia-Jun Yan, Jian-Hua Cai, Zhong-Yi Dong, Zi-Zhen Zhang

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Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Hao-Yu ZhangDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Muerzhate AimaitiDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Long BaiDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Meng-Qing YuanThe Hongkong University of Science and Technology, Hongkong, China.
Chun-Chao ZhuDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jia-Jun YanDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jian-Hua CaiDepartment of General Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China. jianhuacai@139.com.
Zhong-Yi DongDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. firgun123@sjtu.edu.cn.
Zi-Zhen ZhangDepartment of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhangzizhen@renji.com.

Funding

The National Natural Science Foundation of China 81972206
6 · The paper itself

Abstract

backgroundThe expansion of function-preserving surgery became possible due to a more profound understanding of gastric cancer (GC), and T1N + or T2N + gastric cancer patients might be potential beneficiaries. However, ways to evaluate the possibility of function-preserving pylorus surgery are still unknown.

methodsA total of 288 patients at Renji Hospital and 58 patients at Huadong Hospital, pathologically diagnosed with gastric cancer staging at T1 and T2 with tumors located in the upper two-thirds of the stomach, were retrospectively enrolled from March 2015 to October 2022. Tumor regions of interest (ROIs) were manually delineated on bi-phase CT images, and a nomogram was built and evaluated.

resultsThe radiomic features distributed differently between positive and negative pLNm groups. Two radiomic signatures (RS1 and RS2) and one clinical signature were constructed. The radiomic signatures exhibited good performance for discriminating pLNm status in the test set. The three signatures were then combined into an integrated nomogram (IN). The IN showed good discrimination of pLNm in the Renji cohort (AUC 0.918) and the Huadong cohort (AUC 0.649). The verification models showed high values.

conclusionFor GC patients with T1 and T2 tumors located in the upper two-thirds of the stomach, a nomogram was successfully built for predicting pylorus lymph node metastasis, which would guide the surgical indication extension of conservative gastrectomies.

Indexed as

Lymphatic MetastasisNomogramsPylorusStomach NeoplasmsTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingPreoperative CareRadiomicsRetrospective StudiesFunction-preserving surgeryGastric cancerNomogramRadiomics

Identifiers

PMID39225717

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