Evidence map›Paper›PMID 39225634›Full record

ArticleAging2024

Genetic effect of thyroid function-related diseases on acute respiratory distress syndrome: a Mendelian randomization study.

Peilong Li, Haifeng Liu, Feng Li, Mingze Sui, Kai Liu, Hongmin Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peilong LiChildren’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China.
Haifeng LiuChildren’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China.
Feng LiChildren’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China.
Mingze SuiChildren’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China.
Kai LiuChildren’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China.
Hongmin FuChildren’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown an association between acute respiratory distress syndrome (ARDS) and thyroid function. However, their causal relationship remains unspecified. Therefore, this study aims to explore the causal relationship between ARDS and thyroid function-related diseases with Mendelian Randomization (MR) analysis.

methodsARDS dataset finn-b-J10_ARDS, finn-b-E4_THYROID dataset of disorders of the thyroid gland (DTG) and finn-b-E4_HYTHYNAS of hypothyroidism were acquired from public database. In univariate MR (UVMR), causal effects between DTG, hypothyroidism and ARDS were investigated using 5 types of algorithms, and reliability was validated by sensitivity analysis. Moreover, multivariate MR (MVMR), enrichment and interaction network analyses of genes corresponding to SNPs of DTG and hypothyroidism were carried out. Significant level was chosen as p<0.05.

resultsUVMR identified DTG and hypothyroidism (

conclusionsUVMR and MVMR analysis revealed a causal connection between DTG and hypothyroidism as risk factors with ARDS, providing robust evidence for investigation into relationship of hypothyroidism on ARDS and between DTG and ARDS.

Indexed as

Mendelian Randomization AnalysisPolymorphism, Single NucleotideRespiratory Distress SyndromeGenetic Predisposition to DiseaseHumansHypothyroidismRisk FactorsThyroid DiseasesThyroid GlandARDSdisorders of the thyroid glandenrichment analysishypothyroidismMendelian randomization

Identifiers

PMID39225634
PMCPMC11424573

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.