Evidence map›Paper›PMID 39225628›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.

Ben Lin, Zhen Ye, Zhan Cao, Zhao Ye, Yifei Yu, Weiliang Jiang, Sichen Guo, Vladimir Melnikov, Peng Zhou, Chenxing Ji and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Ben LinDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Zhen YeDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Zhan CaoDepartment of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Zhao YeDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Yifei YuDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Weiliang JiangDepartment of Gastroenterology, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Sichen GuoShanghai Medical College, Fudan University, Shanghai, 200032, China.
Vladimir MelnikovDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Peng ZhouDepartment of Cardiology, Huashan Hospital Fudan University, Shanghai, 200040, China.
Chenxing JiDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Chengzhang ShiDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Zerui WuDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Zhengyuan ChenDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Yihua XuDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Qilin ZhangDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Zengyi MaDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Nidan QiaoDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Long ChenDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Xuefei ShouDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Xiaoyun CaoDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Xiang ZhouDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Li ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Min HeDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Yongfei WangDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.
Hongying YeDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Yiming LiDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Zhaoyun ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Meng WangDepartment of Endocrinology and Metabolism, Huashan Hospital Fudan University, Shanghai, 200040, China.
Renyuan GaoDepartment of General Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Yichao ZhangDepartment of Neurosurgery, Huashan Hospital Fudan University, Shanghai, 200040, China.ORCID 0000-0001-8880-4457

Funding

National Natural Science Foundation of China 81970716National Natural Science Foundation of China 81972221National Natural Science Foundation of China 82170841National Natural Science Foundation of China 82200921National Natural Science Foundation of China 82202906National Natural Science Foundation of China 82370656National Project in Promoting The Diagnosis And Treatment Of Major Diseases by MDTNatural Science Foundation of Shanghai Municipality 23ZR1450900Shanghai Science and Technology Development Foundation 17YF426700
6 · The paper itself

Abstract

Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, and cognitive impairments. The roles of gut microbiome and serum metabolome in CP-associated hypothalamic comorbidities are aimed to be explored. Patients with CP are characterized by increased Shannon diversity, Eubacterium, Clostridium, and Roseburia, alongside decreased Alistipes and Bacteroides. CP-enriched taxa are positively correlated with dyslipidemia and cognitive decline, while CP-depleted taxa are negatively associated with fatty liver. Subsequent serum metabolomics identified notably up-regulated purine metabolism, and integrative analysis indicated an association between altered microbiota and elevated hypoxanthine. Phenotypic study and multi-omics analysis in the Rax-CreER

Indexed as

CraniopharyngiomaGastrointestinal MicrobiomeMetabolomeAdultAnimalsComorbidityDisease Models, AnimalFemaleHumansHypothalamusMaleMiceMiddle AgedPituitary Neoplasmscraniopharyngiomasgut microbiotahypothalamus‐pituitary axisserum metabolome

Identifiers

PMID39225628
PMCPMC11497089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.