Trial reportRadiology2024
MRI Predicts Residual Disease and Outcomes in Watch-and-Wait Patients with Rectal Cancer.
Abstract readRandomized Controlled Trial
In one paragraph
Trial report in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Watch-and-Wait strategy for locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a comprehensive review.Frontiers in oncology · 2026Pooled it
- CT-derived extracellular volume fraction and AI-assisted body composition for predicting neoadjuvant therapy response and prognosis in colorectal cancer.Abdominal radiology (New York) · 2026Article
- Oral and gut microbiota profiles in patients with locally advanced rectal cancer with varying responses to neoadjuvant chemoradiotherapy.Functional & integrative genomics · 2026Observational
- Report from the 27th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Calgary, Alberta, 26-27 September 2025: Advances in Colon and Rectal Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Watch and Wait Strategy for Locally Advanced Rectal Cancer: Update From Results of Recent Clinical Trials.Cancer medicine · 2026Review
- Magnetic Resonance Imaging After Total Neoadjuvant Therapy in Rectal Cancer: Treatment-Oriented Response Assessment and Reporting for Watch-and-Wait Management.Korean journal of radiology · 2026Review
- Challenges in rectal cancer MRI: from image acquisition to interpretation.Abdominal radiology (New York) · 2026Review
- Pelvic MRI Following Total Neoadjuvant Therapy for Rectal Cancer Poorly Predicts a Complete Clinical Response.Journal of surgical oncology · 2026Article
- Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis.Clinical and translational radiation oncology · 2026Article
- Review
- MRI's evolving role in rectal cancer in the era of personalized medicine.Abdominal radiology (New York) · 2026Review
- Diffusion-weighted imaging in rectal cancer MRI from theory to practice.Abdominal radiology (New York) · 2026Review
- Deep learning reconstruction accelerated reduced field-of-view DWI in rectal cancer: mucosa-submucosa-muscularis visualization and T staging.European radiology experimental · 2026Article
- Molecularly informed preoperative and response-adapted management of colorectal cancer: evidence, decision boundaries, and emerging directions.Frontiers in oncology · 2026Review
- Accuracy of Flexible Sigmoidoscopy and MRI in Restaging Rectal Cancer after Neoadjuvant Therapy: A Secondary Analysis of the OPRA Randomized Clinical Trial.Annals of surgery · 2025Article
- Diagnosing Complete Response to Preoperative Chemoradiation in Esophageal Cancer Using Dynamic Contrast-Enhanced MRI Response Criteria.Korean journal of radiology · 2025Article
- Correlations between Apparent Diffusion Coefficient (ADC) and Prognosis in Patients with Locally Advanced Rectal Cancer.Life (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Hannah Williams *From the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0001-8928-4190
Dana M Omer *From the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Hannah M ThompsonFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0003-3405-5184
Sabrina T LinFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0001-7535-2535
Floris S VerheijFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0001-7834-7336
Joao MirandaFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0003-1273-3108
Jonathan B YuvalFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0002-9251-8303
James BuckleyFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0009-0004-2146-5023
Michael R MarcoFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Li-Xuan QinFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
David A DombroskiFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0009-0004-3665-1873
Rajendra KedarFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0009-0008-9501-9690
Aytekin OtoFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Elena KorngoldFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0003-2642-5472
Joseph C VenieroFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0001-8198-7019
Sunil GandhiFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0009-0009-2471-1337
Arun KrishnarajFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0003-3928-7064
Minal JagtianiFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0009-0004-3568-9909
Kirk OhanianFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Dan VuFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Thomas A HopeFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0002-2228-5823
Sonia LeeFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Ashish P WasnikFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0002-4823-8929
Nikhil MadhuripanFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0009-0004-8772-5406
Marc J GollubFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0002-6008-0730
Julio Garcia-AguilarFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).ORCID 0000-0003-2451-0948
OPRA ConsortiumFrom the Departments of Surgery, Colorectal Service (H.W., D.M.O., H.M.T., F.S.V., J.B.Y., J.B., M.R.M., J.G.A.), Epidemiology and Biostatistics (S.T.L., L.X.Q.), and Radiology (J.M., M.J.G.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065; Department of Radiology, University of Rochester Medical Center, Rochester, NY (D.A.D.); Department of Radiology, University of South Florida, Tampa, Fla (R.K.); Department of Radiology, University of Chicago, Chicago, Ill (A.O.); Department of Radiology, Oregon Health and Science University, Portland, Ore (E.K.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (J.C.V.); Department of Radiology, John Muir Health, Walnut Creek, Calif (S.G.); Department of Radiology, University of Virginia, Charlottesville, Va (A.K.); Department of Radiology, University of Washington, Seattle, Wash (M.J.); Department of Radiology, St Joseph Hospital Orange County, Orange, Calif (K.O., D.V.); Department of Radiology, University of California San Francisco, San Francisco, Calif (T.A.H.); Department of Radiology, University of California Irvine, Irvine, Calif (S.L.); Department of Radiology, University of Michigan, Ann Arbor, Mich (A.P.W.); and Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colo (N.M.).
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MSURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7MAutomated Measurement of Bowel Damage Using Enterography Imaging to Predict Clinical Outcomes in Crohn’s Disease.R01DK124779 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STIDHAM, RYAN WILLIAM · 2020 to 2023
$2.1MInvestigating the contribution of cellular senescence to the efficacy of radiation therapy.K08CA255574 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ROMESSER, PAUL BERNARD · 2021 to 2025
$1.2MNCI NIH HHS K08 CA255574NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA009501NIDDK NIH HHS R01 DK124779
Abstract
Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have not evaluated its ability to accurately select patients for nonoperative management. Purpose To evaluate the ability of restaging MRI to predict oncologic outcomes and identify imaging features associated with residual disease (RD) after TNT. Materials and Methods This was a secondary analysis of the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial, which randomized participants from April 2014 to March 2020 with stages II or III rectal adenocarcinoma to undergo either induction or consolidation TNT. Participants enrolled in the OPRA trial who underwent restaging MRI were eligible for inclusion in the present study. Radiologists classified participants as having clinical complete response (cCR), near-complete clinical response (nCR), or incomplete clinical response (iCR) based on restaging MRI at a mean of 8 weeks ± 4 (SD) after treatment. Oncologic outcomes according to MRI response category were assessed using Kaplan-Meier curves. Logistic regression analysis was performed to identify imaging characteristics associated with RD. Results A total of 277 participants (median age, 58 years [IQR, 17 years]; 179 male) who were randomized in the OPRA trial had restaging MRI forms completed. The median follow-up duration was 4.1 years. Participants with cCR had higher rates of organ preservation compared with those with nCR (65.3% vs 41.6%, log-rank
Indexed as
Magnetic Resonance ImagingNeoplasm, ResidualRectal NeoplasmsAdenocarcinomaAdultAgedFemaleHumansMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPredictive Value of TestsProspective StudiesTreatment OutcomeWatchful Waiting
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