Evidence map›Paper›PMID 39224925›Full record

ArticleTurkish journal of pharmaceutical sciences2024

Timolol Maleate

Özlem Kral, Eda Turan Ayhan, Sibel Ilbasmıs-Tamer, Fahriye Figen Tırnaksız

Abstract read
In one paragraph

Article in Turkish journal of pharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Özlem KralGazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye.ORCID 0000-0003-1420-8462
Eda Turan AyhanAdıyaman University Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Adıyaman, Türkiye.ORCID 0000-0002-1381-3196
Sibel Ilbasmıs-TamerGazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye.ORCID 0000-0003-0361-7105
Fahriye Figen TırnaksızGazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye.ORCID 0000-0003-3970-653X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The aim of this study was to prepare a sustained-delivery mucoadhesive-thermosensitive formulation containing poloxamer 338 (P338), poloxamer 188 (P188), and mucoadhesive agents, such as chitosan (CHT) and carboxymethylcellulose (CMC), to increase the ophthalmic bioavailability of timolol maleate (TM). Materials and Methods: Gels were prepared by mixing different amounts of P338, P188, and a mucoadhesive agent in cold isotonic water using a magnetic stirrer. The sol-gel gelation time of the gels was determined using the test tube inversion method. Viscosity measurements and analysis of the mechanical properties of the gel formulations were performed. Results: The gelation times of formulations containing 20:2.5 (P338:P188) and 0.1% CMC and formulations containing 20:2.5 (P338:P188) and 0.1% CHT were 35 s and 26.67 s, respectively. An optimally selected CHT mucoadhesive-thermosensitive Conclusion: The improved mucoadhesive-thermosensitive

Indexed as

carboxymethyl cellulosechitosanmucoadhesive-thermosensitiveophthalmic gelpoloxamerTimolol maleate

Identifiers

PMID39224925
PMCPMC11589094

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.