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ArticleTechnical innovations & patient support in radiation oncology2024

Adaptive brachytherapy for cervical cancer in combined 1.5 T MR/HDR suite: Impact of repeated imaging.

Katelijne M Van Vliet-van den Ende, Paulien G Hoogendoorn-Mulder, Rogier I Schokker, Marinus A Moerland, Petra S Kroon, Judith M Roesink, Raquel Dávila Fajardo, Femke Van der Leij, Ina M Jürgenliemk-Schulz

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In one paragraph

Article in Technical innovations & patient support in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Breakthroughs in modern brachytherapy are transforming cancer care.Physics and imaging in radiation oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katelijne M Van Vliet-van den EndeDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Paulien G Hoogendoorn-MulderDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Rogier I SchokkerDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Marinus A MoerlandDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Petra S KroonDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Judith M RoesinkDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Raquel Dávila FajardoDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Femke Van der LeijDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Ina M Jürgenliemk-SchulzDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: At our department we have a dedicated 1.5 Tesla MRI/HDR brachytherapy suite, which provides the possibility of repeated MRI scanning before, during and after applicator insertion and before and/or after irradiation for patients with advanced cervical cancer. In this study we analysed the effect of this adaptive workflow. We investigated the number of interventions, their impact on organ doses (OAR) and the respective dose differences between total prescribed and total delivered doses. Materials and methods: Seventy patients with locally advanced cervical cancer FIGO2009 stages IB-IVA, treated from June 2016 till August 2020, were retrospectively analysed. The standard brachytherapy schedule consisted of two applicator insertions and delivery of three or four HDR fractions.OARs were recontoured on the repeated MRI scans. The D Results: In total 153 interventions were performed, 3 replacements of the applicator, 23 adaptations of needle positions, bladder filling was changed 74 times and repeated rectal degassing 53 times. The impact of the rectal interventions was on average -1.2 Gy EQD2 Conclusions: An MRI scanner integrated into the brachytherapy suite enables multiple interventions based on the scans before treatment planning and dose delivery. This allows for customized treatment according to the changing anatomy of the individual patient and a better estimation of the delivered dose.

Indexed as

Adaptive workflowCervical cancerMRI guided brachytherapyOARsRepeated imaging

Identifiers

PMID39224832
PMCPMC11367091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.