Evidence map›Paper›PMID 39224600›Full record

ArticleFrontiers in immunology2024

GSDMD is associated with survival in human breast cancer but does not impact anti-tumor immunity in a mouse breast cancer model.

Bart Boersma, Viola Puddinu, Arnaud Huard, Sébastien Fauteux-Daniel, Pratyaksha Wirapati, Sofia Guedri, Jean-Christophe Tille, Thomas McKee, Mikael Pittet, Gaby Palmer and 1 more

Abstract read
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Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pyroptosis: Turning Up the Heat on Cancer.Annual review of immunology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bart BoersmaSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Viola PuddinuSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Arnaud HuardDepartment of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Sébastien Fauteux-DanielDepartment of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Pratyaksha WirapatiDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Sofia GuedriSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Jean-Christophe TilleDivision of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.
Thomas McKeeDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Mikael PittetDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Gaby PalmerDepartment of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Carole BourquinSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation plays a pivotal role in cancer development, with chronic inflammation promoting tumor progression and treatment resistance, whereas acute inflammatory responses contribute to protective anti-tumor immunity. Gasdermin D (GSDMD) mediates the release of pro-inflammatory cytokines such as IL-1β. While the release of IL-1β is directly linked to the progression of several types of cancers, the role of GSDMD in cancer is less clear. In this study, we show that GSDMD expression is upregulated in human breast, kidney, liver, and prostate cancer. Higher

Indexed as

Breast NeoplasmsIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsTumor MicroenvironmentAnimalsCell Line, TumorCytokinesDisease Models, AnimalFemaleGasderminsHumansLiver NeoplasmsMiceMice, KnockoutCytokinesGasderminsGSDMD protein, humanGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding Proteinsbreast cancercancer immunologygasdermin DimmunotherapyToll-like receptor 7

Identifiers

PMID39224600
PMCPMC11366651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.