Evidence map›Paper›PMID 39224595›Full record

ArticleFrontiers in immunology2024

Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to

Aseervatham Anusha Amali, Kathirvel Paramasivam, Chiung Hui Huang, Abhinav Joshi, Jayshree L Hirpara, Sharada Ravikumar, Qi Hui Sam, Rachel Ying Min Tan, Zhaohong Tan, Dilip Kumar and 7 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aseervatham Anusha Amali *Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.
Kathirvel Paramasivam *Mechanobiology Institute, National University of Singapore, Singapore, Singapore.
Chiung Hui HuangDepartment of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, Singapore, Singapore.
Abhinav JoshiUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, United States.
Jayshree L HirparaCancer Science Institute, National University of Singapore, Singapore, Singapore.
Sharada RavikumarDivision of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.
Qi Hui SamDivision of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.
Rachel Ying Min TanDivision of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.
Zhaohong TanDivision of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.
Dilip KumarSingapore Immunology Network (SIgN), ASTAR (Agency for Science, Technology and Research), Singapore, Singapore.
Leonard M NeckersUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, United States.
Shazib PervaizDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Roger FooCardiovascular Research Institute, National University Health System, Singapore, Singapore.
Candice Y Y ChanDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Jin ZhuMechanobiology Institute, National University of Singapore, Singapore, Singapore.
Cheryl Lee *Cardiovascular and Metabolic Disorders, Duke NUS Medical School, Singapore, Singapore.
Louis Yi Ann Chai *Division of Infectious Diseases, Department of Medicine, National University Health System, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular chaperons stabilize protein folding and play a vital role in maintaining tissue homeostasis. To this intent, mitochondrial molecular chaperons may be involved in the regulation of oxidative phosphorylation and apoptosis during stress events such as infections. However, specific human infectious diseases relatable to defects in molecular chaperons have yet to be identified. To this end, we performed whole exome sequencing and functional immune assessment in a previously healthy Asian female, who experienced severe respiratory failure due to

Indexed as

ApoptosisHSP90 Heat-Shock ProteinsPneumocystis cariniiPneumonia, PneumocystisCaspase 3Caspase 7Disease SusceptibilityExome SequencingFemaleGenetic Predisposition to DiseaseHumansMiddle AgedMitochondriaCaspase 3Caspase 7HSP90 Heat-Shock ProteinsTRAP1 protein, humanapoptosiscaspaseglycolysismitochondriaopportunistic infectionoxidative phosphorylation

Identifiers

PMID39224595
PMCPMC11368041

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.