Evidence map›Paper›PMID 39224590›Full record

ArticleFrontiers in immunology2024

A future of AI-driven personalized care for people with multiple sclerosis.

Jelle Praet, Lina Anderhalten, Giancarlo Comi, Dana Horakova, Tjalf Ziemssen, Patrick Vermersch, Carsten Lukas, Koen van Leemput, Marjan Steppe, Cristina Aguilera and 8 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Mechanistic Insights into the Role of Artificial Intelligence and Machine Learning in the Diagnosis and Management of Multiple Sclerosis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Review
  3. From lesion detection to outcome prediction: artificial intelligence and deep learning applications in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jelle Praet *icometrix NV, Leuven, Belgium.
Lina Anderhalten *Experimental and Clinical Research Center (ECRC), A Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Giancarlo ComiDepartment of Neurorehabilitative Sciences, Casa di Cura Igea, Italy.
Dana HorakovaDepartment of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.
Tjalf ZiemssenCenter of Clinical Neuroscience, Department of Neurology, University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany.
Patrick VermerschUniv. Lille, InsermU1172 LilNCog, CHU Lille, FHU Precise, Lille, France.
Carsten LukasInstitute of Neuroradiology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany.
Koen van LeemputAthinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Marjan SteppeEuropean Charcot Foundation, Brussels, Belgium.
Cristina AguileraSYNAPSE Research Management Partners, Madrid, Spain.
Ella Maria KadasNocturne GmbH, Berlin, Germany.
Alexis BertrandAB Science, Clinical Development, Paris, France.
Jean van RampelberghImcyse SA, Liège, Belgium.
Erik de BoerBristol-Myers Squibb Company Corp, Princeton, NJ, United States.
Vera ZinglerF. Hoffmann-La Roche Ltd., Product Development Medical Affairs, Neuroscience, Basel, Switzerland.
Dirk Smeetsicometrix NV, Leuven, Belgium.
Annemie Ribbens *icometrix NV, Leuven, Belgium.
Friedemann Paul *Experimental and Clinical Research Center (ECRC), A Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a devastating immune-mediated disorder of the central nervous system resulting in progressive disability accumulation. As there is no cure available yet for MS, the primary therapeutic objective is to reduce relapses and to slow down disability progression as early as possible during the disease to maintain and/or improve health-related quality of life. However, optimizing treatment for people with MS (pwMS) is complex and challenging due to the many factors involved and in particular, the high degree of clinical and sub-clinical heterogeneity in disease progression among pwMS. In this paper, we discuss these many different challenges complicating treatment optimization for pwMS as well as how a shift towards a more pro-active, data-driven and personalized medicine approach could potentially improve patient outcomes for pwMS. We describe how the 'Clinical Impact through AI-assisted MS Care' (CLAIMS) project serves as a recent example of how to realize such a shift towards personalized treatment optimization for pwMS through the development of a platform that offers a holistic view of all relevant patient data and biomarkers, and then using this data to enable AI-supported prognostic modelling.

Indexed as

Artificial IntelligenceMultiple SclerosisPrecision MedicineBiomarkersDisease ProgressionHumansPrognosisQuality of LifeBiomarkersAIdatadiagnosisdisease progressionmultiple sclerosispersonalized medicineprognosis

Identifiers

PMID39224590
PMCPMC11366570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.