Evidence map›Paper›PMID 39224444›Full record

ArticleClinical case reports2024

Kawasaki disease with profound systemic vascular involvements: An insightful pediatric case.

Naila Nadeem, Muhammad Nadeem Ahmad, Muhammad Haseeb Malik, Mallick Muhammad Zohaibuddin, Muhammad Ahmed, Faheemullah Khan, Hatem Eltaly, Uffan Zafar

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naila NadeemDepartment of Radiology The Aga Khan University Hospital Karachi Pakistan.
Muhammad Nadeem AhmadDepartment of Radiology The Aga Khan University Hospital Karachi Pakistan.
Muhammad Haseeb MalikDepartment of Radiology Quaid-e-Azam Medical College Bahawalpur Punjab Pakistan.
Mallick Muhammad ZohaibuddinDepartment of Radiology The Aga Khan University Hospital Karachi Pakistan.
Muhammad AhmedDepartment of Radiology The Aga Khan University Hospital Karachi Pakistan.
Faheemullah KhanCleveland Clinic Main Campus Hospital Cleveland Ohio USA.
Hatem EltalyCleveland Clinic Main Campus Hospital Cleveland Ohio USA.ORCID https://orcid.org/0009-0000-9934-3887
Uffan ZafarDepartment of Radiology The Aga Khan University Hospital Karachi Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key Clinical Message: Kawasaki disease (KD), a self-limiting vasculitis, can present with a broader spectrum of vascular involvements, necessitating early recognition and prompt management. This case exemplifies the importance of involving multiple teams on board in managing complex presentations of KD. It also highlights the importance of close monitoring for the progression of the disease spectrum as well as family education to ensure favorable outcomes. The case also emphasizes the importance of long-term follow-up and further research to understand the prognosis, early screening tools, and possible complications due to multi-organ involvement in KD along with their management strategies. Abstract: Kawasaki disease (KD) is a multisystem vascular inflammatory syndrome, which predominantly affects the small and medium vessels in children within the age group of less than 5 years. The most threatened complication is the development of coronary artery aneurysms (CAAs). We present an extremely rare case of KD in a 2-month, 21-day-old male infant with extensive vascular involvement, expanding the disease spectrum beyond the involvement of coronary arteries. These included aneurysmal dilatations of both internal carotid arteries, the descending aorta, bilateral multilevel intercostal arteries, coeliac artery, superior mesenteric artery, and both renal arteries. Implementing a multidisciplinary approach with early treatment via intravenous immunoglobulin (IVIG) and dexamethasone proved to be most effective in the patient's management. Despite unique challenges such as severe coronary dilation and pseudomonas sepsis during the special care, the patient was stabilized and discharged after 11 days of hospital stay, highlighting the importance of early prompt management and a centered approach to evaluate in a broader spectrum. This case emphasizes the importance of long-term follow-up and further research to understand the prognosis, early screening tools, and possible complications due to multi-organ involvement in KD along with their management strategies.

Indexed as

aneurysmschildrenKawasaki diseasevascular inflammatory syndrome

Identifiers

PMID39224444
PMCPMC11366678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.