Evidence map›Paper›PMID 39224276›Full record

ArticleHeliyon2024

Spinal RAMP1-mediated neuropathic pain sensitisation in the aged mice through the modulation of CGRP-CRLR pain signalling.

Yi Qin, Xuemei Chen, Zhangjie Yu, Xiaoxin Zhou, Yihao Wang, Qi Li, Wanbing Dai, Yizhe Zhang, Sa Wang, Yinghui Fan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yi QinDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Xuemei ChenDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Zhangjie YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Xiaoxin ZhouDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Yihao WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Qi LiDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Wanbing DaiDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Yizhe ZhangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Sa WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Yinghui FanDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Jie XiaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Diansan SuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Yingfu JiaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Weifeng YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain sensitivity varies depending on both the state and age of an individual. For example, chronic pain is more common in older individuals, but the underlying mechanisms remain unknown. This study revealed that 18-month-old mice (aged) experienced more severe and long-lasting allodynia and hyperalgesia in the chronic constriction injury (CCI)-induced pain state compared to 2-month-old mice. Interestingly, the aged mice had a higher baseline mechanical pain threshold than the adult mice. The expression of spinal receptor-active modification protein 1 (RAMP1), as a key component and regulator of the calcitonin gene-related peptide (CGRP) receptor for nociceptive transmission from the periphery to the spinal cord, was reduced in the physiological state but significantly increased after CCI in the aged mice compared to the adult mice. Moreover, when RAMP1 was knocked down using shRNA, the pain sensitivity of adult mice decreased significantly, and CCI-induced allodynia in aged mice was reduced. These findings suggest that spinal RAMP1 is involved in regulating pain sensitivity in a state- and age-dependent manner. Additionally, interfering with RAMP1 could be a promising strategy for alleviating chronic pain in older individuals.

Indexed as

AgeingCGRPChronic painRAMP1Spinal dorsal horn (SDH)

Identifiers

PMID39224276
PMCPMC11367041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.