ArticleBiochimica et biophysica acta1985
Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat.
Article in Biochimica et biophysica acta, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 128 citations in OpenAlex.
- Cutaneous Redox Senescence.Biomedicines · 2024Review
- Stable analogs of 13‑hydroxy-9,10-trans-epoxy-(11E)-octadecenoate (13,9-HEL), an oxidized derivative of linoleic acid implicated in the epidermal skin barrier.Prostaglandins, leukotrienes, and essential fatty acids · 2021Article
- AnJournal of biological methods · 2020Review
- 12R-lipoxygenase activity is reduced in photodamaged facial stratum corneum. A novel activity assay indicates a key function in corneocyte maturation.International journal of cosmetic science · 2019Article
- Linoleate-enriched diet increases both linoleic acid esterified to omega hydroxy very long chain fatty acids and free ceramides of canine stratum corneum without effect on protein-bound ceramides and skin barrier function.Archives of dermatological research · 2018Article
- A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.Science signaling · 2017Article
- Novel Fish Oil-based Bigel System for Controlled Drug Delivery and its Influence on Immunomodulatory Activity of Imiquimod Against Skin Cancer.Pharmaceutical research · 2017Article
- The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE.The Journal of biological chemistry · 2016Article
- Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.The Journal of biological chemistry · 2011Article
- Enhanced topical delivery and ex vivo anti-inflammatory activity from a betamethasone dipropionate formulation containing fish oil.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism.Journal of lipid research · 2008Review
- The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Review
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- Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia.The Journal of clinical investigation · 1994Article
- Modulation of phorbol ester-associated events in epidermal cells by linoleate and arachidonate.Lipids · 1993Article
- Article
- Increased plasma triglyceride secretion in EFA-deficient rats fed diets with or without saturated fat.Lipids · 1989Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential fatty acids are absolutely necessary for maintaining the proper condition of the water barrier (stratum compactum) in the skin. Even direct topical application of linoleic acid or any other Z,Z-(n-6, n-9)-fatty acid to the skin restores the barrier in essential fatty acid-deficient animals. In order to investigate the mechanism by which these polyunsaturated fatty acids exert their activity, radioactively labelled fatty acids were applied to the skin of the live animal and the epidermal lipids were analysed after 1-4 days. Much radioactivity was incorporated into two peculiar lipids, viz. acyl ceramide and acyl acid, which are characteristic of the barrier, in which linoleate was esterified to the end-position of very-long-chain (C30-34) unsaturated omega-hydroxy fatty acids. Strong evidence was obtained which showed that these lipids carry linoleate into the barrier layer where it is converted, probably by lipoxygenase(s), into a series of peroxidated lipids. The lipoxygenase inhibitor, eicosatetraynoic acid, prevents both oxygenation of the polyunsaturated fatty acid and the formation of a healthy skin. This peroxidation may supply the mediators which induce the proper differentiation of the epidermal cells into an effective stratum compactum and a horny layer.
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