Evidence map›Paper›PMID 39223998›Full record

ArticleEuropean journal of haematology2024

Perinatal Outcomes Following Intravenous Iron for Treatment of Iron Deficiency With and Without Anemia.

Kimberly S Ryan, Kylee L Martens, Bharti Garg, Boris I Chobrutskiy, Madeline A Hedges, Olivia L Hagen, Jean M G Sabile, Adam K Lewkowitz, Methodius G Tuuli, Thomas G Deloughery and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kimberly S RyanDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
Kylee L MartensDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-5379-8202
Bharti GargDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
Boris I ChobrutskiyDepartment of Internal Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Madeline A HedgesDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
Olivia L HagenDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0009-0001-0369-5819
Jean M G SabileDepartment of Internal Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Adam K LewkowitzDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.
Methodius G TuuliDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.
Thomas G DelougheryDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-5790-4700
Joseph J ShatzelDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-9396-5976
Jamie O LoDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-1934-1935
Ashley E BensonDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Impact of maternal marijuana use on epigenetic regulation of offspring neurodevelopmentDP1DA056493 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jamie Lo · 2022 to 2026
$2.6M
Evaluating the Safety and Efficacy of Targeting the Contact Pathway to Prevent Device Associated Thrombosis.R01HL151367 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHATZEL, JOSEPH JAMES · 2020 to 2024
$1.5M
American Society of HematologyNHLBI NIH HHS R01 HL151367NHLBI NIH HHS R01HL151367NIDA NIH HHS DP1 DA056493NIDA NIH HHS DP1 DA056793NIDA NIH HHS P51-OD-011092NIH HHS P51 OD011092Silver Family Foundation
6 · The paper itself

Abstract

objectiveTo determine maternal and neonatal outcomes in individuals with iron deficiency receiving antepartum intravenous (IV) iron supplementation, stratified by the degree of anemia. STUDY

designRetrospective cohort study of iron-deficient pregnant patients who received at least one IV infusion of iron (iron sucrose, low molecular weight iron dextran [LMWID], or ferric carboxymaltose) during their pregnancy from January 1, 2011 through June 16, 2022. Our primary outcomes included both neonatal composite morbidity and maternal composite morbidity in the context of maternal anemia.

resultsPatients who received LMWID had fewer infusion visits, received higher total doses of iron and had a more substantial correction of hemoglobin compared to those who received iron sucrose (p < 0.01). Maternal anemia at the time of admission was not associated with neonatal composite morbidity. However, there was a significant association between anemia status and maternal composite outcome (p = 0.05). Anemia at time of delivery was associated with the likelihood of requiring a blood transfusion (p = 0.01).

conclusionThis study reinforces previous findings emphasizing the adverse effects of iron deficiency on maternal health and the role of IV iron in reducing these risks.

Indexed as

Anemia, Iron-DeficiencyIronPregnancy OutcomeAdministration, IntravenousAdultFemaleHumansInfant, NewbornPregnancyPregnancy Complications, HematologicRetrospective StudiesTreatment OutcomeIronanemiaintravenous ironironiron deficiencymaternal iron deficiencypregnancy

Identifiers

PMID39223998
PMCPMC11632358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.