Evidence map›Paper›PMID 39223706›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2024

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases.

Ashley P Dudey, Jake M Rigby, Gregory R Hughes, G Richard Stephenson, Thomas E Storr, Andrew Chantry, Andrew M Hemmings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashley P DudeySchool of Biological Sciences, University of East Anglia, Norwich, UK.
Jake M RigbySchool of Chemistry, Pharmacy & Pharmacology, University of East Anglia, Norwich, UK.
Gregory R HughesSchool of Biological Sciences, University of East Anglia, Norwich, UK.
G Richard StephensonSchool of Chemistry, Pharmacy & Pharmacology, University of East Anglia, Norwich, UK.
Thomas E StorrSchool of Chemistry, Pharmacy & Pharmacology, University of East Anglia, Norwich, UK.
Andrew ChantrySchool of Biological Sciences, University of East Anglia, Norwich, UK.
Andrew M HemmingsSchool of Biological Sciences, University of East Anglia, Norwich, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC

Indexed as

Dose-Response Relationship, DrugMolecular Docking SimulationUbiquitin-Protein LigasesEnzyme InhibitorsHumansMolecular StructureStructure-Activity RelationshipEnzyme InhibitorsUbiquitin-Protein LigasesWWP1 protein, humanWWP2 protein, humandrug discoverySARubiquitin ligase inhibitorsWWP1WWP2

Identifiers

PMID39223706
PMCPMC11373361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.