Evidence map›Paper›PMID 39223389›Full record

SynthesisNeurosurgical review2024

Does it stable? Intracranial aneurysm wall enhancement might be the warning signals: a meta-analysis of observational studies.

Jiajie Gu, Shuxiong Ge, Xiaosheng Chen, Xiaojia Zhang, Shiling Chen, Zhou Lu, Huixiao Wang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiajie GuDepartment of Neurosurgery, People's Hospital Affiliated of Ningbo University, East Baizhang Rd 251th, Yinzhou, Zhejiang, 315100, China. 1652413468@qq.com.
Shuxiong GeDepartment of Vascular Surgery, People's Hospital Affiliated of Ningbo University, East Baizhang Rd 251th, Yinzhou, Zhejiang, 315100, China.
Xiaosheng ChenDepartment of Neurosurgery, People's Hospital Affiliated of Ningbo University, East Baizhang Rd 251th, Yinzhou, Zhejiang, 315100, China.
Xiaojia ZhangDepartment of Neurosurgery, People's Hospital Affiliated of Ningbo University, East Baizhang Rd 251th, Yinzhou, Zhejiang, 315100, China.
Shiling ChenCollege of Medicine, Ningbo University, Ningbo, Zhejiang, China.
Zhou LuDepartment of Neurosurgery, People's Hospital Affiliated of Ningbo University, East Baizhang Rd 251th, Yinzhou, Zhejiang, 315100, China.
Huixiao WangDepartment of Neurosurgery, People's Hospital Affiliated of Ningbo University, East Baizhang Rd 251th, Yinzhou, Zhejiang, 315100, China.

Funding

the Chinese Medicine S&T programs, project of Zhejiang Province 2023ZL657
6 · The paper itself

Abstract

Magnetic resonance vessel wall imaging (MR-VWI) is an emerging imaging technology used to assess the progressive risk of unruptured intracranial aneurysms (UIAs). Unlike the standard evaluation model, MR-VWI is still debatable. This study aims to further define the potential relationship between aneurysm wall enhancement (AWE) and aneurysm stability. Using "intracranial aneurysm", "magnetic resonance", and "enhancement" as keywords, relevant studies were systematically searched in PubMed, Embase, and Cochrane, and the qualified studies were enrolled for further analysis. There were 13 case-control studies, 4 cohort studies, and 2,678 cases of intracranial aneurysms included in the meta-analysis. It was shown that AWE was correlated with intracranial aneurysm rupture (OR = 35.90, 95% CI: 15.58 to 82.75, p < 0.001), growth (OR = 6.69, 95% CI: 2.69 to 16.63, p < 0.001), and presence of symptoms (OR = 14.46, 95% CI: 9.07 to 23.05, p < 0.001). This finding had a high diagnostic value, but the correlation was probably not independent of aneurysm size. The pooled relative risks of the follow-up studies revealed that the risk of UIA progression was approximately 3.33 times higher with AWE than without AWE (RR = 3.33, 95% CI: 2.33 to 4.78, p < 0.001). In addition, the pooled results demonstrated that quantitative indices of VWI enhancement were equally linked with aneurysm stability (OR = 19.61, 95% CI: 10.63 to 36.17, p < 0.001). AWE is an effective imaging method to assess the stability of UIAs, and it can be a marker for the prophylactic treatment of small unruptured intracranial aneurysms in the future, which remains to be validated by prospective studies with large samples.

Indexed as

Intracranial AneurysmAneurysm, RupturedHumansMagnetic Resonance ImagingObservational Studies as TopicAneurysm wall enhancementIntracranial aneurysmMagnetic resonanceMeta-analysisVessel wall imaging

Identifiers

PMID39223389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.