ArticleNature biotechnology2025
Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells.
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Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
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Who cites it
59 citing papers in PubMed.
- Article
- Article
- Induced pluripotent stem cells from discovery to translation.Nature medicine · 2026Review
- RUNX1+23 enhancer marks erythro-megakaryocyte lineages in early waves of hematopoiesis in human ESC differentiation.Blood advances · 2026Article
- SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome.Leukemia · 2026Article
- Harnessing intermediate-scale bioreactors for next-generation macrophage production and application.Nature protocols · 2026Review
- Pathogenic myeloid phenotypes drive disease pathology in a novel human neurohistiocytosis model.Blood · 2026Article
- Transcriptional landscape of direct reprogramming toward the hematopoietic lineage.bioRxiv : the preprint server for biology · 2026Article
- WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm.Stem cell reports · 2026Article
- Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates.bioRxiv : the preprint server for biology · 2026Article
- Application of spatial transcriptomics across organoids for a high-resolution, spatial whole-transcriptome benchmarking dataset.iScience · 2026Article
- Retinoic acid as a stage-specific modulator of hematopoietic lineage fate from human pluripotent stem cells.Cell communication and signaling : CCS · 2026Article
- Engineering bone marrow in a dish-a bloody business: preclinical opportunities, translational use cases, and a call for consensus.Journal of thrombosis and haemostasis : JTH · 2026Review
- Human stem cell-based embryo models: innovation, ethics, and policy.Human reproduction (Oxford, England) · 2026Article
- Generation of therapeutic T cells from human induced pluripotent stem cells.Inflammation and regeneration · 2026Review
- Macrophages orchestrate antiviral defense and epithelial repair in a human iPSC-derived alveolar air-liquid interface.JCI insight · 2026Article
- Modeling human B cell development with pluripotent stem cells.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of the Effects of 50 Hz Magnetic Field Exposure on the Human Hematopoietic System in Humanized Mice.Bioelectromagnetics · 2026Article
- Efficient and robust generation of functional hematopoietic cells from human pluripotent stem cells in albumin-free conditions.Stem cells translational medicine · 2026Article
- Retinoic acid regulates the development of human definitive hematopoiesis in a non-cell-autonomous manner.Development (Cambridge, England) · 2026Article
Corrections and comments
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Authors and funding
22 authors.
Elizabeth S NgMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia. elizabeth.ng@mcri.edu.au.ORCID http://orcid.org/0000-0002-7970-8129
Gulcan Sarila *Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Jacky Y Li *Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Hasindu S EdirisingheMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Ritika SaxenaMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-5412-2255
Shicheng SunMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-9584-9909
Freya F BruverisMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Tanya LabonneMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Nerida SleebsMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Alexander MaytumMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Raymond Y YowMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Chantelle InguantiMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Ali MotazedianMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Vincenzo CalvaneseDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
Sandra Capellera-GarciaDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5680-242X
Feiyang MaDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6260-0787
Hieu T NimMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Mirana RamialisonMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-6315-4777
Constanze BoniferMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Hanna K A MikkolaDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
Edouard G Stanley *Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-6389-3665
Andrew G Elefanty *Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia. andrew.elefanty@mcri.edu.au.ORCID http://orcid.org/0000-0001-6448-8314
Funding
Mapping human hematopoietic stem cell developmentR01DK125097 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKKOLA, HANNA KATRI ANNIKKI · 2021 to 2023
$917kCalifornia Institute for Regenerative Medicine (CIRM) RT3-07763Department of Health | National Health and Medical Research Council (NHMRC) GNT1068866, GNT1129861, GNT1186019Department of Health | National Health and Medical Research Council (NHMRC) GNT1068866, GNT1129861, GNT2012535Department of Health | National Health and Medical Research Council (NHMRC) GNT1079004, GNT1068866, GNT1129861, GNT1186019Department of Health | National Health and Medical Research Council (NHMRC) GNT1117596,GNT1068866, GNT1129861,GNT2012535Department of Health | National Health and Medical Research Council (NHMRC) GNT1164577, GNT2012936Department of Health | National Health and Medical Research Council (NHMRC) GNT1186019Department of Health | National Health and Medical Research Council (NHMRC) GNT2012535Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) NIH 1RO1DK125097-01NIDDK NIH HHS R01 DK125097Novo Nordisk Fonden (Novo Nordisk Foundation) NNF21CC0073729RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/R014809/1Vetenskapsrådet (Swedish Research Council) IPD2 2018-06635
Abstract
Hematopoietic stem cells (HSCs) derived from human induced pluripotent stem cells (iPS cells) have important biomedical applications. We identified differentiation conditions that generate HSCs defined by robust long-term multilineage engraftment in immune-deficient NOD,B6.Prkdc
Indexed as
Cell DifferentiationHematopoietic Stem CellsHematopoietic Stem Cell TransplantationInduced Pluripotent Stem CellsAnimalsCell LineageHumansMiceMice, Inbred NOD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.