ArticleCommunications biology2024
Cell-specific effects of temporal interference stimulation on cortical function.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Progresses on temporal interference electromagnetic stimulation for non-invasive deep brain function modulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Pooled it
- Magnetoelectric Nanoparticles Enable Modulation of Cortical Networks by Low-Intensity Static Magnetic Fields In Vitro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neural dynamics of temporal interference stimulation monitoring by soft liquid metal interfaces across neural systems.Nature communications · 2026Article
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Temporal Interference Electrical Stimulation for Neuropsychiatric Disorders: Mechanisms, Applications, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Transcranial temporal interference stimulation for treating bipolar disorder with depressive episodes: a feasibility Study.Molecular psychiatry · 2025Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Review
- The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves.Nature communications · 2025Article
- Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
- Excitation and polarization of isolated neurons by high-frequency sine waves for temporal interference stimulation.Cell reports. Physical science · 2025Article
- Beyond the surface: a review of transcranial temporal interference stimulation for deep brain modulation.Frontiers in neurology · 2025Review
- Cell-specific effects of temporal interference stimulation on cortical function.Communications biology · 2024Article
- Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Temporal interference (TI) stimulation is a popular non-invasive neurostimulation technique that utilizes the following salient neural behavior: pure sinusoid (generated in off-target brain regions) appears to cause no stimulation, whereas modulated sinusoid (generated in target brain regions) does. To understand its effects and mechanisms, we examine responses of different cell types, excitatory pyramidal (Pyr) and inhibitory parvalbumin-expressing (PV) neurons, to pure and modulated sinusoids, in intact network as well as in isolation. In intact network, we present data showing that PV neurons are much less likely than Pyr neurons to exhibit TI stimulation. Remarkably, in isolation, our data shows that almost all Pyr neurons stop exhibiting TI stimulation. We conclude that TI stimulation is largely a network phenomenon. Indeed, PV neurons actively inhibit Pyr neurons in the off-target regions due to pure sinusoids (in off-target regions) generating much higher PV firing rates than modulated sinusoids in the target regions. Additionally, we use computational studies to support and extend our experimental observations.
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Registered trials
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