ArticleNature communications2024
Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Stage-aware transcriptomics reveals selective haplotype persistence in short-termbioRxiv : the preprint server for biology · 2026Article
- A common DNA deletion altering the 3'UTR of mdr1 is associated with reduced mefloquine susceptibility in P. vivax parasites from Cambodian patients.Nature communications · 2026Article
- Degradation of ribosomal RNA duringmBio · 2025Article
- Low-volumeMicrobial genomics · 2025Article
- A common DNA deletion altering the 3'UTR ofResearch square · 2025Article
- Novel single-cell preservation and RNA sequencing technology unlocks field studies for Plasmodium natural infections.Scientific reports · 2025Article
- A chromosome-scale genome assembly of Giardia duodenalis by long-read sequencing of ten trophozoites.Scientific data · 2025Article
- Degradation of ribosomal RNA duringbioRxiv : the preprint server for biology · 2025Article
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Abstract
Most Plasmodium vivax infections contain genetically distinct parasites, but the consequences of this polyclonality on the development of asexual parasites, their sexual differentiation, and their transmission remain unknown. We describe infections of Saimiri monkeys with two strains of P. vivax and the analyses of 80,024 parasites characterized by single cell RNA sequencing and individually genotyped. In our model, consecutive inoculations fail to establish polyclonal infections. By contrast, simultaneous inoculations of two strains lead to sustained polyclonal infections, although without detectable differences in parasite regulation or sexual commitment. Analyses of sporozoites dissected from mosquitoes fed on coinfected monkeys show that all genotypes are successfully transmitted to mosquitoes. However, after sporozoite inoculation, not all genotypes contribute to the subsequent blood infections, highlighting an important bottleneck during pre-erythrocytic development. Overall, these studies provide new insights on the mechanisms regulating the establishment of polyclonal P. vivax infections and their consequences for disease transmission.
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