Evidence map›Paper›PMID 39222964›Full record

Trial reportAIDS care2024

Acceptability of an automated directly observed therapy (DOT) application for PrEP adherence support among young men who have sex with men: a qualitative exploration.

Jennifer Velloza, Albert Y Liu, Ariana W K Katz, Ariane van der Straten, Aaron J Siegler, Hyman Scott, Gretchen Wilde, Annie Lockard, Richard H Christie, Susan P Buchbinder

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. User Input in the Development of Digital Sexual Health Tools: A Scoping Review and Guidance for Tool Developers.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer VellozaDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Albert Y LiuBridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.
Ariana W K KatzRTI International, Women's Global Health Imperative, Berkeley, CA, USA.
Ariane van der StratenCenter for AIDS Prevention Studies, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Aaron J SieglerDepartment of Behavioral Sciences and Health Education, Emory University, Atlanta, GA, USA.
Hyman ScottBridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.
Gretchen WildeDepartment of Epidemiology, Emory University, Atlanta, GA, USA.
Annie LockardDepartment of Epidemiology, Emory University, Atlanta, GA, USA.
Richard H ChristieAiCure, New York, NY, USA.
Susan P BuchbinderBridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.

Funding

DOT Diary (D2): Developing a mobile app with combined automated DOT and daily sexual diary for monitoring and improving PrEP adherenceR01MH109320 · NIMH · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI BUCHBINDER, SUSAN · 2015 to 2018
$3.9M
NIMH NIH HHS R01 MH109320
6 · The paper itself

Abstract

Pre-exposure prophylaxis (PrEP) adherence remains a challenge among young men who have sex with men (MSM). We developed and tested a smartphone application ("app"), "DOT Diary", which combines automated directly observed therapy (DOT) with information about PrEP protection levels, pill-taking reminders, a sexual behavior diary, and a PrEP dosing calendar. To contextualize trial results, we qualitatively explored participants' app experiences. The trial enrolled 100 young MSM in San Francisco and Atlanta. Participants were randomized 2:1 to DOT Diary versus standard-of-care and followed for 24 weeks. Interviews were conducted with 24 intervention participants. Data were analyzed using a memo-writing approach. Most expressed overall satisfaction with the app ("it was good for its purpose"), despite concerns about technical glitches. The most popular app features were the monthly calendar showing days PrEP was taken and information about level of protection based on pills taken. The DOT component helped participants establish PrEP routines. The reminders were "annoying but effective" at motivating dosing. Opinions about the sexual behavior diary varied. Overall, DOT Diary was acceptable; participants were willing to use it daily to record pill-taking. Critical components included the information about PrEP protection levels and calendar, while others may be modified to improve future success.

Indexed as

Directly Observed TherapyHIV InfectionsHomosexuality, MaleMedication AdherenceMobile ApplicationsPre-Exposure ProphylaxisAdolescentAdultAnti-HIV AgentsGeorgiaHumansMalePatient Acceptance of Health CareQualitative ResearchReminder SystemsSan FranciscoAnti-HIV Agentsacceptabilitydirectly observed therapy (DOT)mobile health (mHealth)Pre-exposure prophylaxis (PrEP)SDG 10: Reduced inequalitiesSDG 3: Good health and well-being

Identifiers

PMID39222964
PMCPMC11511627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.