Evidence map›Paper›PMID 39222505›Full record

ArticleAnnals of internal medicine2024

Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort.

Diana L Miglioretti, Linn Abraham, Brian L Sprague, Christoph I Lee, Michael C S Bissell, Thao-Quyen H Ho, Erin J A Bowles, Louise M Henderson, Rebecca A Hubbard, Anna N A Tosteson and 1 more

Abstract read
In one paragraph

Article in Annals of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Individual-Level Trends in Mammography Screening over 14 years: Results from an All-Payer Statewide Claims Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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  13. Mammo-GAN-Assisted Deep Network Training Scheme for Lesion Detection.Journal of imaging informatics in medicine · 2025
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  18. Ethical Considerations and Implications of Multi-Cancer Early Detection Screening: Reliability, Access and Cost to Test and Treat.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Diana L MigliorettiDivision of Biostatistics, Department of Public Health Sciences, University of California, Davis, School of Medicine, Davis, California, and Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington (D.L.M.).ORCID 0000-0002-5547-1833
Linn AbrahamKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington (L.A., E.J.A.B.).ORCID 0000-0002-0840-1947
Brian L SpragueDepartment of Surgery, Office of Health Promotion Research, Larner College of Medicine at the University of Vermont and University of Vermont Cancer Center, Burlington, Vermont (B.L.S.).
Christoph I LeeDepartment of Radiology, University of Washington School of Medicine; Department of Health Systems and Population Health, University of Washington School of Public Health; and Hutchinson Institute for Cancer Outcomes Research, Seattle, Washington (C.I.L.).ORCID 0000-0002-8185-7721
Michael C S BissellPicnicHealth, San Francisco, California (M.C.S.B.).ORCID 0000-0002-2414-4573
Thao-Quyen H HoDepartment of Training and Scientific Research, University Medical Center, and Breast Imaging Unit, Diagnostic Imaging Center, Tam Anh General Hospital, Ho Chi Minh City, Vietnam (T.H.H.).ORCID 0000-0001-6314-937X
Erin J A BowlesKaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington (L.A., E.J.A.B.).ORCID 0000-0001-6287-7391
Louise M HendersonDepartment of Radiology, University of North Carolina, Chapel Hill, North Carolina (L.M.H.).ORCID 0000-0001-8356-9267
Rebecca A HubbardDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (R.A.H.).ORCID 0000-0003-0879-0994
Anna N A TostesonThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth and Dartmouth Cancer Center, Lebanon, New Hampshire (A.N.A.T.).ORCID 0000-0001-7718-8943
Karla KerlikowskeGeneral Internal Medicine Section, Department of Veterans Affairs, and Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California (K.K.).ORCID 0000-0001-8793-8779

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KARLA M KERLIKOWSKE · 2011 to 2026
$52.9M
Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Susan L SANTANGELO · 2017 to 2026
$51.6M
Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and OutcomesR01CA266377 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LEE, CHRISTOPH I · 2021 to 2025
$3.1M
Group Health Cancer Research Program Research Specialist AwardR50CA211115 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI BOWLES, ERIN JANELLE AIELLO · 2017 to 2021
$919k
NCI NIH HHS P01 CA154292NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA266377NCI NIH HHS R50 CA211115NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

backgroundFalse-positive results on screening mammography may affect women's willingness to return for future screening.

objectiveTo evaluate the association between screening mammography results and the probability of subsequent screening.

designCohort study.

setting177 facilities participating in the Breast Cancer Surveillance Consortium (BCSC). PATIENTS: 3 529 825 screening mammograms (3 184 482 true negatives and 345 343 false positives) performed from 2005 to 2017 among 1 053 672 women aged 40 to 73 years without a breast cancer diagnosis. MEASUREMENTS: Mammography results (true-negative result or false-positive recall with a recommendation for immediate additional imaging only, short-interval follow-up, or biopsy) from 1 or 2 screening mammograms. Absolute differences in the probability of returning for screening within 9 to 30 months of false-positive versus true-negative screening results were estimated, adjusting for race, ethnicity, age, time since last mammogram, BCSC registry, and clustering within women and facilities.

resultsWomen were more likely to return after a true-negative result (76.9% [95% CI, 75.1% to 78.6%]) than after a false-positive recall for additional imaging only (adjusted absolute difference, -1.9 percentage points [CI, -3.1 to -0.7 percentage points]), short-interval follow-up (-15.9 percentage points [CI, -19.7 to -12.0 percentage points]), or biopsy (-10.0 percentage points [CI, -14.2 to -5.9 percentage points]). Asian and Hispanic/Latinx women had the largest decreases in the probability of returning after a false positive with a recommendation for short-interval follow-up (-20 to -25 percentage points) or biopsy (-13 to -14 percentage points) versus a true negative. Among women with 2 screening mammograms within 5 years, a false-positive result on the second was associated with a decreased probability of returning for a third regardless of the first screening result. LIMITATION: Women could receive care at non-BCSC facilities.

conclusionWomen were less likely to return to screening after false-positive mammography results, especially with recommendations for short-interval follow-up or biopsy, raising concerns about continued participation in routine screening among these women at increased breast cancer risk. PRIMARY FUNDING SOURCE: National Cancer Institute.

Indexed as

Breast NeoplasmsEarly Detection of CancerMammographyAdultAgedCohort StudiesFalse Positive ReactionsFemaleHumansMass ScreeningMiddle AgedUnited States

Identifiers

PMID39222505
PMCPMC11970968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.