Evidence map›Paper›PMID 39222353›Full record

ReviewMicrobiology (Reading, England)2024

Microbial Primer: Phase variation - survival and adaptability by generation of a diverse population.

Ashley J Fraser, Finn E McMahon, John M Atack

Abstract readReview
In one paragraph

Review in Microbiology (Reading, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashley J FraserInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, Queensland 4215, Australia.
Finn E McMahonInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, Queensland 4215, Australia.
John M AtackInstitute for Biomedicine & Glycomics, Griffith University, Gold Coast, Queensland 4215, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phase variation is defined as the rapid and reversible switching of gene expression, and typically occurs in genes encoding surface features in small genome bacterial pathogens. Phase variation has evolved to provide an extra survival mechanism in bacteria that lack multiple 'sense-and-respond' gene regulation systems. Many bacterial pathogens also encode DNA methyltransferases that are phase-variable, controlling systems called 'phasevarions' (phase-variable regulons). This primer will summarize the current understanding of phase variation, describing the role of major phase-variable factors, and phasevarions, in bacterial pathobiology.

Indexed as

BacteriaGene Expression Regulation, BacterialAdaptation, PhysiologicalBacterial Physiological PhenomenaBacterial ProteinsRegulonBacterial Proteinscontingency/survival strategyinverted repeatsphase variationphasevarionsimple sequence repeats

Identifiers

PMID39222353
PMCPMC11475388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.