Evidence map›Paper›PMID 39222330›Full record

ReviewEFORT open reviews2024

Advanced therapies in orthopaedics.

Tobias Winkler, Sven Geissler, Tazio Maleitzke, Carsten Perka, Georg N Duda, Alexander Hildebrandt

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EFORT open reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07434115 (Clinical and Functional Evaluation of Orthobiological Therapies in Musculoskeletal Conditions), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07434115 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinical and Functional Evaluation of Orthobiological Therapies in Musculoskeletal Conditions

TypeinterventionalSponsorPROREGENRan2026 to 2030Enrolled300ConditionsMusculoskeletal Diseases or ConditionsArmsPRP injection, Bone Marrow Concentrate (BMAC), Hyaluronic Acid (Viscosupplementation), Nanofat
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tobias WinklerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.ORCID 0000-0003-0727-4680
Sven GeisslerBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany.
Tazio MaleitzkeBerlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Carsten PerkaCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.
Georg N DudaCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.
Alexander HildebrandtCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced therapies are expected to play a crucial role in supporting repair after injury, halting the degeneration of musculoskeletal tissue to enable and promote physical activity. Despite advancements, the progress in developing advanced therapies in orthopaedics lags behind specialties like oncology, since innovative regenerative treatment strategies fall short of their expectations in musculoskeletal clinical trials. Researchers should focus on understanding the mechanism of action behind the investigated target before conducting clinical trials. Strategic research networks are needed that not only enhance scientific exchange among like-minded researchers but need to include early on commercial views, companies and venture perspectives, regulatory insights and reimbursement perspectives. Only in such collaborations essential roadblocks towards clinical trials and go-to-patients be overcome.

Indexed as

advanced therapiesbiomaterialscell therapydegenerationgene therapyorthobiologics

Identifiers

PMID39222330
PMCPMC11457816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.