Evidence map›Paper›PMID 39222300›Full record

ArticleAnnals of surgical oncology2024

Laparoscopic Treatment of Wilms' Tumor: Criteria of SIOP-UMBRELLA Protocol may be Updated.

Morgan Pradier, Sabine Irtan, Hubert Ducou Le Pointe, François Becmeur, Raphaël Moog, Julien Rod, Aurore Haffreingue, Marc-David Leclair, Hubert Lardy, Aurélien Binet and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Morgan PradierService de chirurgie pédiatrique, CHU, Saint Etienne, France. morgan_p@hotmail.fr.
Sabine IrtanService de chirurgie pédiatrique, Hôpital Armand Trousseau - AP-HP, Sorbonne Université, Paris, France.
Hubert Ducou Le PointeService de radiologie pédiatrique, Hôpital Armand Trousseau - AP-HP, Sorbonne Université, Paris, France.
François BecmeurService de chirurgie pédiatrique, CHU, Strasbourg, France.
Raphaël MoogService de chirurgie pédiatrique, CHU, Strasbourg, France.
Julien RodService de chirurgie pédiatrique, CHU, Caen, France.
Aurore HaffreingueService de chirurgie pédiatrique, CHU, Caen, France.
Marc-David LeclairService de chirurgie pédiatrique, CHU, Nantes, France.
Hubert LardyService de chirurgie pédiatrique, CHU, Tours, France.
Aurélien BinetService de chirurgie pédiatrique, CHU, Tours, France.
Frédéric LavrandService de chirurgie pédiatrique, CHU, Bordeaux, France.
Pascale Philippe-ChometteService de chirurgie pédiatrique, Hôpital Universitaire Robert-Debré (AP-HP), National Reference Center (CRMR) « MARVU » (Rare Maformations of the Urinary Tract), INSERM UMR1141 NeuroDev, Université Paris Cité, Paris, France.
Matthieu PeycelonService de chirurgie pédiatrique, Hôpital Universitaire Robert-Debré (AP-HP), National Reference Center (CRMR) « MARVU » (Rare Maformations of the Urinary Tract), INSERM UMR1141 NeuroDev, Université Paris Cité, Paris, France.
Florent GuerinService de chirurgie pédiatrique, Hôpital Kremlin Bicêtre- AP-HP, Paris, France.
Aurore BoutyService de chirurgie pédiatrique, HCL-HFME, Lyon, France.
Arnauld VerschuurService d'hématologie, d'immunologie et de cancérologie pédiatrique, AP-HM Timone, Marseille, France.
François VarletService de chirurgie pédiatrique, CHU, Saint Etienne, France.
Aurélien ScalabreService de chirurgie pédiatrique, CHU, Saint Etienne, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTotal nephrectomies for the treatment of Wilms' tumor (WT) are more and more performed by laparoscopy, although indications for this approach following the UMBRELLA guidelines are currently very restrictive. The purpose of this study was to assess the compliance to the criteria of the UMBRELLA protocol for minimally invasive approach of WT.

methodsThis retrospective multicenter study included children operated on by laparoscopic total nephrectomy for suspected WT before 2020. Imaging was reviewed centrally.

resultsFifty-six patients (50 WT and 6 nephrogenic rests) were operated on at a median age of 3.3 ± 2.6 years. Thirteen (23%) patients had metastasis at diagnosis. The mean operative time was 213 ± 84 min. There were eight (14.3%) conversions and five peroperative complications. A local stage III was confirmed in seven (12.5%) cases, including two for tumor rupture. Only one (1.8%) of the procedures followed the SIOP-UMBRELLA indications for laparoscopy. The criterion "ring of normal parenchyma" was met only once. Conservative surgery seemed possible in ten (17.9%) cases. The extension of the tumor beyond the ipsilateral edge of the vertebra after chemotherapy and a volume over 200 mL were associated with an increased risk of conversion (p = 0.0004 and p = 0.001 respectively). After a mean follow-up of 5.2 ± 4.0 years, although there was no local recurrence, one death occurred due to metastatic progression at 15 months postoperatively.

conclusionsThe laparoscopic approach of WT beyond the UMBRELLA recommendations was feasible with low risk of local recurrence. Its indications may be updated and validated.

Indexed as

Kidney NeoplasmsLaparoscopyNephrectomyWilms TumorChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantMalePractice Guidelines as TopicPrognosisRetrospective StudiesSurvival RateChildLaparoscopyNephroblastomaRadical nephrectomySIOP-UMBRELLA protocolWilms’ tumor

Identifiers

PMID39222300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.