Evidence map›Paper›PMID 39222184›Full record

ArticleAIDS and behavior2025

A Cautionary Tale: Digital Clinical Trial Implementation of a Couples-Based HIV Prevention Study among Transgender Women and Their Partners in the United States.

Kristi E Gamarel, Ellen S Stein, Wesley M Correll-King, Breonna McCree, Jack Johnson, Lance M Pollack, Torsten B Neilands, Mallory O Johnson, Don Operario, Jae M Sevelius

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristi E GamarelDepartment of Health Behavior and Health Equity, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA. kgamarel@umich.edu.ORCID http://orcid.org/0000-0001-9405-7515
Ellen S SteinDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Wesley M Correll-KingDepartment of Health Behavior and Health Equity, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA.
Breonna McCreeDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jack JohnsonDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Lance M PollackDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Torsten B NeilandsDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Mallory O JohnsonDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Don OperarioDepartment of Behavioral, Social, and Health Education Sciences, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Jae M SeveliusDepartment of Psychiatry, Columbia University, New York, NY, USA.

Funding

Scientific/Technical CoreP2CHD041028 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sarah A. Burgard · 2017 to 2026
$6.5M
Training Program for Scientists Conducting Research to Reduce HIV Health DisparitR25MH067127 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily A Arnold, Torsten Brian Neilands · 2003 to 2026
$5.4M
A couples-based approach to HIV prevention for transgender women and their male partnersR01MH115765 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAMAREL, KRISTI E, OPERARIO, DON · 2018 to 2022
$2.9M
A multi-level approach to improve HIV prevention and care for transgender women of colorR01MH129285 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kristi E Gamarel, Jae M. Sevelius · 2022 to 2026
$2.3M
NICHD NIH HHS P2C HD041028NIMH NIH HHS R01 MH115765NIMH NIH HHS R01MH115765NIMH NIH HHS R01 MH129285NIMH NIH HHS R25 MH067127
6 · The paper itself

Abstract

This study investigates baseline differences in couples enrolled in the "It Takes Two" HIV prevention intervention for transgender women and their partners, comparing in-person participation pre-COVID-19 and digital participation during the pandemic. Among 52 couples (40% in-person, 60% digital), bivariate analyses revealed that in-person participants were more likely to be African American, have cisgender male partners, report higher unemployment, incarceration histories, greater relationship stigma, and lower relationship quality. The findings highlight the limitations of digital modalities in engaging transgender women of color and those with structural vulnerabilities. The study emphasizes that reliance on digital methods in HIV research jeopardizes the inclusion of those lacking technological access and literacy, especially communities disproportionately impacted by HIV. Researchers must incorporate hybrid or in-person options and engage communities to ensure equity and inclusion, thus overcoming barriers and ensuring comprehensive population reach in HIV prevention studies.

Indexed as

HIV InfectionsSexual PartnersTransgender PersonsAdultBlack or African AmericanCOVID-19FemaleHumansMaleMiddle AgedSARS-CoV-2Social StigmaUnited StatesWhiteCouples-based HIV Prevention InterventionOnline StudiesTransgender Women

Identifiers

PMID39222184
PMCPMC11747887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.