Evidence map›Paper›PMID 39222150›Full record

ArticleJournal of mathematical biology2024

Error-induced extinction in a multi-type critical birth-death process.

Meritxell Brunet Guasch, P L Krapivsky, Tibor Antal

Abstract read
In one paragraph

Article in Journal of mathematical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meritxell Brunet GuaschSchool of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Edinburgh, EH9 3FD, UK. xell.brunetguasch@ed.ac.uk.ORCID 0009-0004-6180-1685
P L KrapivskyDepartment of Physics, Boston University, Boston, MA, 02215, USA.
Tibor AntalSchool of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Edinburgh, EH9 3FD, UK.

Funding

Centre for Doctoral Training in Mathematical Modelling, Analysis and Computation, University of Edinburgh (GB) EP/S023291/1
6 · The paper itself

Abstract

Extreme mutation rates in microbes and cancer cells can result in error-induced extinction (EEX), where every descendant cell eventually acquires a lethal mutation. In this work, we investigate critical birth-death processes with n distinct types as a birth-death model of EEX in a growing population. Each type-i cell divides independently

Indexed as

Extinction, BiologicalMutationAnimalsCell DeathHumansMathematical ConceptsModels, BiologicalModels, GeneticMutation RateNeoplasms

Identifiers

PMID39222150
PMCPMC11369052

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.