ArticleAnalytical and bioanalytical chemistry2024
Development of a high-throughput UHPLC-MS/MS method for the analysis of Fusarium and Alternaria toxins in cereals and cereal-based food.
Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Modified Mycotoxins in Food: Current Evidence, Key Uncertainties, and Priorities for Risk Assessment.Comprehensive reviews in food science and food safety · 2026Review
- Improving the extraction efficiency on the determination of aflatoxin BMycotoxin research · 2026Article
- Quantification of aflatoxins and sterigmatocystin in walnuts, cashews, pistachios, peanuts, and hazelnuts by using UHPLC-MS/MS following Aspergillus flavus inoculation.Mycotoxin research · 2026Article
- Phenolic Compounds: From Traditional Uses to Innovative Applications and Everything in Between.Molecular nutrition & food research · 2026Review
- Multi-Mycotoxin Quantification in Soy Protein Powders, Soymilk, Soybeans (Journal of agricultural and food chemistry · 2026Article
- A worldwide scientometric analysis of Isotope Dilution ICP-MS over four decades: a critical perspective.Analytical and bioanalytical chemistry · 2026Review
- Mycotoxin occurrence and risk assessment in plant-based meat, cheese, and fish alternatives based on an adapted UHPLC-MS/MS multi-method.Mycotoxin research · 2026Article
- Development of a high-throughput UHPLC-MS/MS multi-method for the analysis of mycotoxins in plant-based milk alternatives as the basis for risk assessment.Frontiers in nutrition · 2025Article
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4 authors.
Funding
Abstract
A QuEChERS (quick, easy, cheap, effective, rugged, and safe)-based multi-mycotoxin method was developed, analyzing 24 (17 free and 7 modified) Alternaria and Fusarium toxins in cereals via ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). A modified QuEChERS approach was optimized for sample preparation. Quantification was conducted using a combination of stable isotope dilution analysis (SIDA) for nine toxins and matrix-matched calibration for ten toxins. Quantification via a structurally similar internal standard was conducted for four analytes. Alternariol-9-sulfate (AOH-9-S) was measured qualitatively. Limits of detection (LODs) were between 0.004 µg/kg for enniatin A1 (ENN A1) and 3.16 µg/kg for nivalenol (NIV), while the limits of quantification were between 0.013 and 11.8 µg/kg, respectively. The method was successfully applied to analyze 136 cereals and cereal-based foods, including 28 cereal-based infant food products. The analyzed samples were frequently contaminated with Alternaria toxins, proving their ubiquitous occurrence. Interestingly, in many of those samples, some modified Alternaria toxins occurred, mainly alternariol-3-sulfate (AOH-3-S) and alternariol monomethyl ether-3-sulfate (AME-3-S), thus highlighting the importance of including modified mycotoxins in the routine analysis as they may significantly add to the total exposure of their parent toxins. Over 95% of the analyzed samples were contaminated with at least one toxin. Despite the general contamination, no maximum or indicative levels were exceeded.
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